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European Academy of Neurology guidance for developing and reporting clinical pr...

Aleksovska, Katina; Kobulashvili, Teia; Costa, João; Zimmermann, Georg; Ritchie, Karen; Reinhard, Carola; Vignatelli, Luca; Fanciulli, Alessandra

Background and purpose: Rare diseases affect up to 29 million people in the European Union, and almost 50% of them affect the nervous system or muscles. Delays in diagnosis and treatment onset and insufficient treatment choices are common. Clinical practice guidelines (CPGs) may improve the diagnosis and treatment of patients and optimize care pathways, delivering the best scientific evidence to all clinicians ...


A systematic review of the characteristics and validity of monitoring technolog...

Godinho, Catarina; Domingos, Josefa; Cunha, Guilherme; Santos, Ana T.; Fernandes, Ricardo; Abreu, Daisy; Gonçalves, Nilza; Matthews, Helen; Isaacs, Tom

"Background: There is growing interest in having objective assessment of health-related outcomes using technology-based devices that provide unbiased measurements which can be used in clinical practice and scientific research. Many studies have investigated the clinical manifestations of Parkinson’s disease using such devices. However, clinimetric properties and clinical validation vary among the different devi...


Quantitative home-based assessment of Parkinson´s symptoms: The SENSE-PARK feas...

Ferreira, Joaquim J.; Godinho, Catarina; Santos, Ana T.; Domingos, Josefa; Abreu, Daisy; Gonçalves, Nilza; Barra, Marcio; Larsen, Frank

"Background: Currently, assessment of symptoms associated with Parkinson’s disease is mainly performed in the clinic. However, these assessments have limitations because they provide only a snapshot of the condition. Methods: The feasibility and usability of an objective, continuous and relatively unobtrusive system (SENSE-PARK System), which consists of wearable sensors (three worn during the day and one worn ...


Quantitative home-based assessment of Parkinson`s symptoms: The SENSE-PARK feas...

Ferreira, Joaquim J.; Godinho, Catarina; Santos, Ana T.; Domingos, Josefa; Abreu, Daisy; Gonçalves, Nilza; Barra, Marcio; Larsen, Frank


Quantitative home-based assessment of Parkinson’s symptoms: The SENSE-PARK feas...

Ferreira, Joaquim J; Godinho, Catarina; Santos, Ana T.; Domingos, Josefa M. M.; Abreu, Daisy; Lobo, Raquel; Gonçalves, Nilza; Barra, Marcio

Background: Currently, assessment of symptoms associated with Parkinson's disease is mainly performed in the clinic. However, these assessments have limitations because they provide only a snapshot of the condition. Methods: The feasibility and usability of an objective, continuous and relatively unobtrusive system (SENSE-PARK System), which consists of wearable sensors (three worn during the day and one worn a...


Clinical parameters and tools for home-based assessment of Parkinson’s disease:...

Ferreira, Joaquim J; Santos, Ana T.; Domingos, Josefa M. M.; Matthews, Helen; Isaacs, Tom; Duffen, Joy; Al-Jawad, Ahmed; Larsen, Frank

Background: Parkinson's disease (PD) is a neurodegenerative disorder with fluctuating symptoms. To aid the development of a system to evaluate people with PD (PwP) at home (SENSE-PARK system) there was a need to define parameters and tools to be applied in the assessment of 6 domains: gait, bradykinesia/hypokinesia, tremor, sleep, balance and cognition. Objective: To identify relevant parameters and assessment ...


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