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COPD: can genetic Background inform about disease heterogeneity?

Marçalo, R. F. Santos; Rodrigues, G.; Córdova, T.; Neves, V.; Neto, S.; Pinheiro, M.; Santos, M. A. S.; Simão, P.; Mendes, A.; Andrade, L.; Marques, A.

People with COPD vary substantially on their pulmonary (e.g., airway obstruction) and extra-pulmonary (e.g., symptoms, functional status) manifestations. The aim of this study was to relate this high heterogeneity to the patient’s genetic Background, namely focusing on polymorphisms associated with COPD and COPD-associated phenotypes and features. Summary statistics for COPD and COPD-associated phenotypes and f...


Are indoor and outdoor opportunities for physical activity related to active be...

Hipólino, N.; Flora, S.; Gordo, J.; Pimenta, S.; Morais, N.; Silva, C. G.; Ribeiro, J.; Silva, F.; Oliveira, A.; Brites-Pereira, M.; Carreira, B. P.

Introduction: Persistent respiratory symptoms at rest and during exertion (e.g., dyspnea, fatigue) play a role on the low physical activity (PA) levels found in people with chronic obstructive pulmonary disease (COPD), but other factors may also be involved. Environmental factors have been shown to impact PA levels in other patient populations, but evidence regarding people with COPD is still scarce. Investigat...


A New RFID‐Identification Strategy Applied to the Marble Extraction Industry

Andrade, L.; Figueiredo, Joao; Tlemçani, M.

This paper aims to improve the marble industry production chain by proposing new technological approaches using the Radio Frequency Identification (RFID) systems. The dynamic capabilities of the RFID read‐write tags allow the storage of physical characteristics of stone blocks, according to electrical, ultrasound and three‐dimensional image characterization tests. These characterization non‐destructive tests al...


COPD as a COVID-19 risk group: is genetic background the reason?

Marçalo, R.; Neto, S.; Pinheiro, M.; Rodrigues, A. J.; Sousa, N.; Santos, M. A. S.; Simão, P.; Valente, C.; Andrade, L.; Marques, A.; Moura, G. R.

People with chronic obstructive pulmonary disease (COPD) constitute one of COVID-19 risk groups for poor prognosis upon infection. Variability in predisposition and clinical response to COVID-19 exist but our understanding of these factors in the COPD population is limited. This study explored the genetic background as a possible answer to COVID-19 infection response heterogeneity, either for the poor prognosis...


Deciphering COPD as a risk group for COVID-19: can we blame genetics?

Marçalo, R.; Neto, S.; Pinheiro, M.; Rodrigues, A. J.; Sousa, N.; Santos, M. A. S.; Simão, P.; Valente, C.; Andrade, L.; Marques, A.; Moura, G. R.

People with chronic obstructive pulmonary disease (COPD) constitute one of COVID-19 risk groups. Variability in predisposition and clinical response to COVID-19 exist but our understanding of these factors in the COPD population is limited. This study explored the genetic background as a possible answer to COVID-19 infection response heterogeneity, either for the poor prognosis in people with COPD or across wor...


Genetic risk for COVID-19 outcomes in COPD and differences among worldwide popu...

Marçalo, R.; Neto, S.; Pinheiro, M.; Rodrigues, A. J.; Sousa, N.; Santos, M. A. S.; Simão, P.; Valente, C.; Andrade, L.; Marques, A.; Moura, G. R.

People with chronic obstructive pulmonary disease (COPD) constitute one of COVID-19 risk groups for poor prognosis upon infection. Variability in predisposition and clinical response to COVID-19 exist but our understanding of these factors in the COPD population is limited. This study explored the genetic background as a possible answer to COVID-19 infection response heterogeneity, either for the poor prognosis...


COPD profiles and treatable traits using minimal resources: identification, dec...

Marques, A.; Souto-Miranda, S.; Machado, A. F.; Oliveira, A.; Jácome, C.; Cruz, J.; Enes, V.; Afreixo, V.; Martins, V.; Andrade, L.; Valente, C.

Introduction: Chronic obstructive pulmonary disease (COPD) is highly heterogeneous and complex. Hence, personalising assessments and treatments to this population across different settings and available resources imposes challenges and debate. Research efforts have been made to identify clinical phenotypes or profiles for prognostic and therapeutic purposes. Nevertheless, such profiles often do not describe tre...


Establishing COPD phenotypes using simple clinical measures

Marques, A.; Machado, A.; Miranda, S.; Jácome, C.; Cruz, J.; Oliveira, A.; Enes, V.; Afreixo, V.; Martins, V.; Andrade, L.; Valente, C.; Ferreira, D.

No abstract available.


Tailoring the Anodic Hafnium Oxide Morphology Using Different Organic Solvent E...

Apolinário, A.; Sousa, CT; Oliveira, G. N.P.; Lopes, A.M.L.; ventura, j.; Andrade, L.; Adélio Mendes; araujo, j. p.

Highly ordered anodic hafnium oxide (AHO) nanoporous or nanotubes were synthesized by electrochemical anodization of Hf foils. The growth of self-ordered AHO was investigated by optimizing a key electrochemical anodization parameter, the solvent-based electrolyte using: Ethylene glycol, dimethyl sulfoxide, formamide and N-methylformamide organic solvents. The electrolyte solvent is here shown to highly affect t...


Effect of relative humidity during the preparation of perovskite solar cells: P...

Mesquita, I.; Andrade, L.; Adélio Mendes

Humidity is one of the main environmental factors that limits performance and stability of perovskite solar cells (PSC); it plays a critical role during the preparation of the perovskite film, influencing the crystal growth. In this work, it is investigated the effect of the relative humidity (RH) and type of atmosphere (nitrogen vs air) used during the deposition of both perovskite layer and hole extraction la...


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