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Chalcone Derivatives with Potential Antimitotic Activity
Silva, Patrícia M. A.; Alves , Eduarda; Cruz , Lara; Santos , Rita; Pereira , Daniela; Assunção, Henrique; Cidade , Honorina; Bousbaa , HassanBackground: Cancer remains one of the leading causes of mortality worldwide, with incidence rates rising in recent years [1]. Among various therapeutic strategies, microtubule-targeting agents have demonstrated significant efficacy in cancer treatment. However, their clinical application is often limited by high toxicity and tumor resistance [2]. Therefore, the discovery of novel small molecules with antitumor ...
KSP and MPS1 kinases as potential therapeutic targets for ovarian cancer
Sampaio, Francisca; Gomes, Carina; Silva, João P. N.; Bousbaa, Hassan; Silva, Patrícia M. A.Background: Ovarian cancer ranks among the top causes of cancer-related deaths in women worldwide [1]. The conventional treatment for ovarian cancer involves surgery and chemotherapy, typically using a combination of paclitaxel and carboplatin [2]. However, despite the initial positive response to this treatment regimen, the development of treatment resistance has emerged as a significant challenge in managing ...
A Pyranoxanthone as a potent antimitotic and sensitizer of cancer cells to low ...
França, Fábio; Silva, Patrícia M. A.; Soares, José X.; Henriques, Ana C.; Loureiro, Daniela R. P.; Azevedo, Carlos M. G.; Afonso, Carlos M. M.Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors the integrity of the mitotic spindle and proper chromosome attachments to microtubules in order to ensure accurat...
Suppression of spindly delays mitotic exit and exacerbates cell death response ...
Silva, Patrícia M. A.; Ribeiro, Nilza; Lima, Raquel T.; Andrade, Claudia; Diogo, Vania; Teixeira, Joana; Florindo, C.; Tavares, AlvaroMicrotubule-targeting agents (MTAs) are used extensively for the treatment of diverse types of cancer. They block cancer cells in mitosis through the activation of the spindle assembly checkpoint (SAC), the surveillance mechanism that ensures accurate chromosome segregation at the onset of anaphase. However, the cytotoxic activity of MTAs is limited by premature mitotic exit (mitotic slippage) due to SAC silenc...