4 documents found, page 1 of 1
Targeting p31comet to Enhance Cisplatin-induced Cytotoxicity in Oral Squamous C...
Ana C. Henriques; João P.N. Silva; Bárbara Pinto; Silva, Patricia M. A.; Hassan Bousbaap31comet plays a crucial role in silencing the spindle assembly checkpoint during mitosis. This study aimed to investigate whether p31comet knockdown could enhance cisplatin-induced cytotoxicity in oral cancer cells. We assessed p31comet expression in oral squamous cell carcinoma (OSCC) cells and examined the impact of p31comet knockdown, cisplatin treatment, and their combination on OSCC cell viability and col...
Exploring the Clinical Relevance of p31comet in Head and Neck Squamous Cell Car...
Henriques, Ana C. Henriques; Silva , João P. N.; Pinto, Bárbara; Silva, Patricia M. A.; Bousbaa, HassanThe p31comet protein plays a pivotal role in regulating spindle assembly checkpoint silencing and is overexpressed in several cancers, including oral cancer. Despite this, its exact roles in tumorigenesis and its prognostic significance remain unclear. In this study, using the UALCAN cancer database, we analyzed p31comet expression and its correlation with clinical indicators in Head and Neck Squamous Cell Carc...
Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implicat...
Silva, Patricia M. A.; Delgado, Maria Leonor; Ribeiro, Nilza; Florindo, Claudia; Tavares, Alvaro A.; Ribeiro, Diana; Lopes, Carlos; do Amaral, BarbasObjectives Bub3 and Spindly are essential proteins required for the activation and inactivation of the spindle assembly checkpoint, respectively. Here, we explored the clinicopathological significance and the therapeutic potential of the opposing roles of the two proteins in oral squamous cell carcinoma (OSCC). Materials and Methods Bub3 and Spindly expression was evaluated by immunohistochemistry in 62 tissue ...
Co-silencing of human Bub3 and dynein highlights an antagonistic relationship i...
Silva, Patricia M. A.; Tavares, Alvaro A.; Bousbaa, HassanWe previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein. Here we examined how this interaction contributes to KT-MT attachments. Depletion of Bub3 or dynein induced misaligned chromosomes, consistent with their role in KT-MT attachments. Unexpected...