14 documents found, page 1 of 2

LAR@MSL Team description paper 2024

The LAR@MSL team has been participating in MSL for many years, from 1999-2007, 2011, 2016 and again in 2023. This Team Description Paper intends to briefly explain the robot’s structure, hardware and software and some of the most important changes implemented by this new team. It is important to point out that new students joined the team and are new to the league. Most of the changes, so far, have been regardi...

The use of a selective, nontoxic dual-acting peptide for breast cancer patients...

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of commonly targeted receptors. Unspecific chemotherapy is currently the main therapeutic option, with poor results. Another major challenge is the frequent appearance of brain metastasis (BM) associated with a significant decrease in patient overall survival. The treatment of BM is even more challenging due to the presen...

Histamine Poisoning, the toxin that escapes through our nose

Histamine Poisoning, the toxin that escapes through our nose

LAR@MSL Description Paper 2023

The LAR@MSL team has been participating on MSL for many years, from 1999-2007, 2011, and 2016. After a few years of stoppage for RoboCup nonrelated reasons, the research team is back to the MSL with a new generation of students. The 2016 robot platforms are being used with some hardware/software changes as the robots were very obsolete and the changes were needed to keep up with the league evolution. This Team ...

Construção e evidências iniciais de validade de uma escala brasileira de identi...

Identidade social é parte do autoconceito de uma pessoa e é construída com base em caracte rísticas associadas a determinadas categorias sociais que o indivíduo faz parte. Atualmente, uma das mais salientes categorias de identidade social é a nacionalidade. O presente estudo apresenta uma nova medida de identificação nacional, desenvolvida para o contexto brasileiro. Para tanto, foram realizados dois estudos. O...

To what extent do fluorophores bias the biological activity of peptides? A prac...

The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These studies frequently depend on the use of fluorescence-based techniques. Since most peptides are not intrinsically fluorescent, they are conjugated to a fluorophore. The conjugation may interfer...

DPepH3, an improved peptide shuttle for receptor-independent transport across t...

Background: The use of peptides as drug carriers across the blood-brain barrier (BBB) has increased significantly during the last decades. PepH3, a seven residue sequence (AGILKRW) derived from the α-helical domain of the dengue virus type-2 capsid protein, translocates across the BBB with very low toxicity. Somehow predictably from its size and sequence, PepH3 is degraded in serum relatively fast. Among strate...

Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived...

There is an urgent need for the development of new anti-HIV drugs that can complement existing medicines to be used against resistant strains. Here, we report the anti-HIV-1 peptide pepRF1, a human serum-resistant peptide derived from the Dengue virus capsid protein. In vitro, pepRF1 shows a 50% inhibitory concentration of 1.5 nM with a potential therapeutic window higher than 53 000. This peptide is specific f...

Structural analysis of a stone arch bridge under incremental railway static loa...

This paper reports on the modelling strategies used to represent the structural behaviour of a masonry single-arch railway bridge. The bridge structural behaviour is simulated by a 3D finite element model, in which the different bridge components are represented by homogeneous materials. The material nonlinear behaviour is simulated using a Drucker-Prager model. The assigned material properties are based on mat...