This is the protocol for a Campbell systematic review. The aim of this scoping review is to map, describe and characterize the available evidence on the role that formal care might have in complementing informal caregivers role – romantic partners, parallel family members (e.g., [step]siblings, cousins or in-laws) or descendants (e.g., the care-receivers are [step]parents, [step]aunts/uncles, [step]grandparents...
Oral appliances (OA) have become one of the most important treatments for obstructive sleep apnea (OSA). Efficacy and compliance have been issues raised with this treatment modality. The new generation OAs, using precision technology, are generally smaller devices occupying less space in the mouth. They create less protrusion of the mandible compared to the classical devices. Previous studies on these devices r...
Social movements can seek to challenge the variety of housing financialisation processes in different ways. Focussing on the case of the Habita association, we examine strategies to contest housing financialisation, which has unfolded through different spatiotemporal dynamics fostered by the State, as well as outcomes of this social mobilisation in Portugal. We emphasise the importance of mixing ‘invited’ strat...
Background: P-glycoprotein (P-gp) is an efflux transporter located at the apical membrane of important barrier tissues, playing a crucial role in the detoxification of endobiotics and xenobiotics [1]. (Thio)xanthonic derivatives have been shown to be able of activating P-gp without increasing its expression, promoting an immediate increase in the amount of transported substrates. Thus, P-gp activation limits th...
Background: New Psychoactive Substances (NPS) pose significant health and legal risks worldwide. At the end of 2021, the European Monitoring Centre for Drugs and Drug Addiction was monitoring 886 NPS, 106 of them phenethylamines [1]. Phenethylamine derivatives include 2,5-dimethoxyphenethylamine-based (2C) and N-benzylphenethylamine-based (NBOMe) drugs, widely known for their psychedelic effects. However, their...
Background: In a society increasingly committed to promoting an active life in the community, new resources are needed to respond to the needs of citizens with Alzheimer’s disease and other forms of dementia. The potential of several individual cognitive interventions to be provided by caregivers has been explored in the literature. Objective: To synthesize the best available evidence on the effectiveness of ca...
Background: Cognitive stimulation (CS) focuses on the intellectual and social stimulation of people with neurocognitive disorders (NCD or dementia). This intervention is widely disseminated in group settings and may not be accessible or adequate to all people with cognitive impairment. Making a Difference 3 (MD3) is an individual CS program in which family (informal) caregivers play the role of home care partne...
[Excerpt] Fungal infections, as recognized by the World Health Organization (WHO), are among the most worrying challenges for the medical community due to their high incidence, recurrence, and the emergence of resistance to the few available drugs and therapies. The discovery of new molecules with antifungal activity, exhibiting new mechanisms of action and less side effects, thus represents an important step f...
Previous studies showed increasing evidence that large firms search for radical innovation as a driver of firm growth, particularly in the research and development sector. Proficiency at innovating via new products remains not merely a key priority for many managers but arguably the ultimate dynamic capability within a firm. However, there is limited understanding of how innovation influences CSR in pharmaceuti...
The GeoMatRe project aims to find low-cost solutions for water and sediment rehabilitation using raw geomaterials, in abandoned mines of the Iberian Pyritic Belt. One of our case studies is the Caveira mine in southwestern Portugal, where large piles of mining waste, containing significant amounts of metals, record the long history of its exploitation for Au and Ag. After the exhaustion of its reserves, the ext...