9 documents found, page 1 of 1
Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from...
Garcia, G.; Nanni, S.; Figueira, I.; Ivanov, I.; McDougall, G. J.; Stewart, D.; Ferreira, R. B.; Pinto, Paula; Silva, R. F. M.; Brites, D.Neuroinflammation is an integral part of the neurodegeneration process inherent to several aging dysfunctions. Within the central nervous system, microglia are the effective immune cells, responsible for neuroinflammatory responses. In this study, raspberries were subjected to in vitro digestion simulation to obtain the components that result from the gastrointestinal (GI) conditions, which would be bioaccessib...
Exploring Multidrug resistance-associated Protein 1 (MRP1) expression during Ne...
Falcao, A.; Torrado, E.; Fernandes, A.; Abranches, E.; Bekman, E.; Brito, A.; Silva, R. F. M.; Henrique, D.; Brites, D.
Inhibition of nitric oxide production prevents apoptotic features mediated by i...
Vaz, A. R.; Silva, S. Leitao; Barateiro, A.; Fernandes, A.; Falcao, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.
Implications of nitrosative stress in apoptotic cascades mediated by pro-inflam...
Vaz, A. R.; Leitão Silva, S.; Barateiro, A.; Fernandes, A.; Falcão, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may p...
Biological risks for neurological abnormalities associated with hyperbilirubinemia
Brites, D.; Fernandes, A.; Falcao, A. S.; Gordo, A. C.; Silva, R. F. M.; Brito, M. A.Unconjugated bilirubin (UCB) injury to glial cells leads to the secretion of glutamate and elicits a typical inflammatory response. Release of pro-inflammatory cytokines may influence gliogenesis and neurogenesis, and lead to deficits in learning and memo. - Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Portugal. - The authors are grateful to the Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Por...
Nitric Oxide mediates Inflammation-Induced Apoptotic Features and Neuronal Dysf...
Vaz, A. R.; Silva, Leitao S.; Barateiro, A.; Falcao, A. S.; Fernandes, A.; Silva, R. F. M.; Brito, M. A.; Brites, D.
Microglia acquires a phagocytic or pro-inflammatory phenotype when bilirubin ge...
Leitão Silva, S.; Osório, C.; Vaz, A. R.; Barateiro, A.; Falcão, A. S.; Brito, M. A.; Fernandes, A.; Silva, R. F. M.; Brites, D.
PREVENTIVE EFFECTS OF BILE ACIDS ON BILIRUBIN-INDUCED APOPTOSIS OF HUMAN BRAIN ...
Correia, M.; Cardoso, F. L.; Sousa, D.; Pamela, I.; Vaz, A. R.; Silva, S. L.; Falcao, A. S.; Fernandes, A.; Silva, R. F. M.; Kim, K. S.; Brites, D.
Role of multidrug resistance-associated protein 1 expression in the in vitro su...
Falcao, A. S.; Bellarosa, C.; Fernandes, A.; Brito, M. A.; Silva, R. F. M.; Tiribelli, C.; Brites, D.Nerve cell injury by unconjugated bilirubin (ILICB) has been implicated in brain damage during neonatal hyperbilirubinemia, particularly in the preterm newborn. Recently, it was shown that UCB is a substrate for the multidrug resistance-associated protein