5 documents found, page 1 of 1
Cervical Cancer Prevention: The Angolan Case
Andrade, P.; Silva, RA; Rocha, HCervical cancer is the leading cause of cancer-related mortality in Angola, posing significant challenges to the country’s health system. This situation is the result of substantial deficiencies in public health infrastructure, population awareness, and access to preventive services, despite the availability of cost-effective interventions like HPV vaccination and cervical screening. The implementation of organ...
The impact of [c16pyr][amp] on the aggressiveness in breast and prostate cancer...
Vieira, FQ; Marques-Magalhães, Â; Miranda-Gonçalves, V; Ferraz, R; Vieira, M; Prudêncio, C; Jerónimo, C; Silva, RABreast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side effects. Therefore, there is an urgent need for more effective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments we...
Blocking the receptor for interleukin 10 protects mice from lethal listeriosis
Silva, RA; Appelberg, RHigh doses of Listeria monocytogenes overcome the ability of a normal mouse to control the infection, due to massive bacterial replication. Treatment with an anti-interleukin 10 (IL-10) receptor monoclonal antibody prevented the fatal course of infection with high doses of bacteria. This work shows that blocking the receptor for IL-10 may have useful therapeutic applications.
Effects of interleukin-12 in the long-term protection conferred by a Mycobacter...
Silva, RA; Pais, TF; Appelberg, RThe effects of the addition of recombinant interleukin (IL)-12 to a mycobacterial subunit vaccine were analyzed in terms of the longevity of the protective immunity generated. BALB/c mice were immunized with culture filtrate proteins from Mycobacterium avium with dimethyl-dioctadecilammonium bromide (DDA) as an adjuvant. This subunit vaccine induced protection against a challenge by M. avium which lasted for at...
Minor role played by type I tumour necrosis factor receptor in the control of M...
Silva, RA; Gomes, MS; Appelberg, RControl of mycobacterial growth depends on the concerted activity of different cytokines acting in different stages of the development of innate and adaptive immune responses. Tumour necrosis factor-alpha (TNF-alpha) has been shown to play a protective role in Mycobacterium avium infections. Here we assessed the growth of this mycobacterial species in wild-type mice and in mice with a genetically engineered dis...