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Anti-corrosion and cytotoxicity properties of inorganic surface treatments on M...

Neves, CS; Sousa, I; Freitas, MA; Moreira, L; Costa, C; Teixeira, JP; Fraga, S; Silva, RM; Silva, RF; Starykevich, M; Scharnagl, N; Zheludkevich, ML

In this work biodegradable Mg1Ca alloy underwent surface modification using hydroxyapatite (HAp), aluminium oxide (Al2O3), and treatments with phosphoric (H3PO4), hydrofluoric (HF), and acetic (CH3COOH) acids. The resulting surface-treated Mg substrates were assessed in terms of phase content and chemical composition through X-ray diffraction (XRD) and glow discharge optical emission spectrometry (GDOES). Addit...


Essential genetic findings in neurodevelopmental disorders

Cardoso, AR; Lopes-Marques, M; Silva, RM; Serrano, C; Amorim, A; Prata, MJ; Azevedo, L

Neurodevelopmental disorders (NDDs) represent a growing medical challenge in modern societies. Ever-increasing sophisticated diagnostic tools have been continuously revealing a remarkably complex architecture that embraces genetic mutations of distinct types (chromosomal rearrangements, copy number variants, small indels, and nucleotide substitutions) with distinct frequencies in the population (common, rare, d...


Progression of myopic maculopathy after treatment of choroidal neovascularization

Farinha, CL; Baltar, AS; Nunes, SG; Figueira, JP; Pires, IA; Cachulo, ML; Silva, RM

Purpose: To evaluate the long-term progression of myopic maculopathy and functional outcome after treatment of myopic choroidal neovascularization (CNV) with photodynamic therapy (PDT) and/or intravitreal ranibizumab (IVR). Methods: Retrospective study with a cross-sectional evaluation. Eyes were assigned to 4 groups (PDT, IVR, PDT + IVR, dry myopic maculopathy) and evaluated with best-corrected visual acuity, ...


Intravitreal ranibizumab for myopic choroidal neovascularization: 12-month results

Silva, RM; Ruiz-Moreno, JM; Rosa, P; Carneiro, A; Nascimento, J; Rito, LF; Cachulo, ML; Carvalheira, F; Murta, JN

PURPOSE: The purpose of this study was to evaluate the safety and efficacy of intravitreal ranibizumab after 12 months in the treatment of choroidal neovascularization secondary to pathologic myopia. METHODS: This was a prospective, multicenter, consecutive, nonrandomized, interventional case series. The study included 34 eyes of 32 patients with choroidal neovascularization secondary to pathologic myopia; 13 e...


Chorioretinal anastomosis and photodynamic therapy:a two-year follow-up study

Silva, RM; Figueira, J; Cachulo, ML; Duarte, L; Faria de Abreu, JR; Cunha-Vaz, JG

BACKGROUND: To evaluate the two-year efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomosis (CRA). METHODS: A non-randomized, institutional, prospective study, of 28 consecutive eyes of 23 patients, with CRA, treated with PDT. Masked best corrected visual acuity (VA) and angiographic features at baseline and during the perio...


Polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin

Silva, RM; Figueira, J; Cachulo, ML; Duarte, L; Faria de Abreu, JR; Cunha-Vaz, JG

BACKGROUND: We evaluated, in a nonrandomised, institutional, prospective study, the efficacy of photodynamic therapy (PDT) with verteporfin in age-related macular degeneration (AMD) eyes with polypoidal choroidal vasculopathy (PCV) and subfoveal exudation. METHODS: A prospective clinical and angiographic study was done in 40 consecutive eyes with PCV treated with PDT using masked best-corrected visual acuity (V...


Stabilization of visual acuity with photodynamic therapy in eyes with chorioret...

Silva, RM; Faria de Abreu, JR; Travassos, A; Cunha-Vaz, JG

PURPOSE: (1) To evaluate, in a non-randomized, institutional, prospective study, the efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomoses (CRA). (2) To review, in a retrospective study and for comparison, the natural evolution of neovascular AMD eyes with CRA. METHODS: Prospective clinical and angiographic study of 17 cons...


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