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Attenuation of capsaicin-induced acute and visceral nociceptive pain by a - and...

Oliveira, Francisco A.; Costa, Charllynton L.S.; Chaves, Mariana H.0; Almeida, Fernanda Regina de Castro; Cavalcante, Ítalo José Mesquita

The triterpene mixture, a - and h -amyrin, isolated from Protium heptaphyllum resin was evaluated on capsaicin- evoked nociception in mice. Orally administered a - and h -amyrin (3 to 100 mg/kg) significantly suppressed the nociceptive behaviors—evoked by either subplantar (1.6 A g) or intracolonic (149 A g) application of capsaicin. The antinociception produced by a - and h -amyrin against subplantar capsaicin...

Date: 2013 | Origin: Oasisbr

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