9 documents found, page 1 of 1
Lactobacillus reuteri DSM 17938 protects agains gastric damage induced by ethan...
Oliveira, Ana P.; Souza, Luan K. M.; Araújo, Thiago S. L.; Araújo, Simone de; Nogueira, Kerolayne M.; Sousa, Francisca Beatriz M.; Silva, Renan O.This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluated the effect of supplementing 108 CFU g body wt1 day1 of DSM on ethanol-induced gastric injury. DSM significantly reduced the ulcer area (1.940 1.121 mm2) with 3 d...
The anti-inflammatory and antinociceptive effects of proteins extracted from Ac...
Leal, Lhaís Suelen Soares; Silva, Renan O.; Araújo, Thiago de Souza Lopes; Silva, Valdelania Gomes da.; Barbosa, André Luiz dos ReisSeeds of Acacia farnesiana are commonly sold in the local markets of northeastern Brazil as a therapeutic agent. The present work aimed to evaluate the anti-inflammatory and analgesic activities of proteins obtained from A. farnesiana seeds. Five different protein fractions (albumin, globulin, prolamin, acidic and basic glutelins) were obtained and investigated for the protein pattern, the presence of hemagglut...
Delivery system for mefenamic acid based on the nanocarrier layered double hydr...
Cunha, Vanessa R. R.; Guilherme, Viviane A.; Paula, Eneida de; Araujo, Daniele R. de; Silva, Renan O.; Medeiros, Jand V. R.; Leite, José R. S. A.Purpose The anionic form of the drug mefenamic acid intercalated into the nanocarrier layered double hydroxide (LDH-Mef) was evaluated by anti-inflammatory and antinociceptive assays. Methods The LDH-Mef material was characterized by a set of physicochemical techniques, which was supported by Density Functional Theory calculations. The pharmacological effects of LDH-Mef (40 wt% of drug) were evaluated by hemoly...
A sulfated-polysaccharide fraction from seaweed gracilaria birdiae prevents nap...
Silva, Renan O.; Santana, Ana Paula M.; Carvalho, Nathalia S.; Bezerra, Talita S.; Oliveira, Camila B.; Damasceno, Samara Rodrigues BonfimAbstract: Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised of substances with pharmaceutical and biomedical potential. The aim of the present study was to evaluate the protective effect of the PLS fraction extracted from the seaweed Gracilaria birdiae in rats with naproxen-induced gastrointestinal damage. Male Wistar rats were pretreated w...
Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammat...
Damasceno, Samara Rodrigues Bonfim; Oliveira, Francisco Rodrigo A.M.; Carvalho, Nathalia S.; Brito, Camila F.C.; Silva, Irismara S.Aims: The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice. Main methods: The anti-inflammatory activity was evaluated using various phlogistic agents that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, pro and anti-inflammatory cytokine levels. Evaluation of antinociceptive activity was...
Role of the NO/KATP pathway in the protective effect of a sulfated-polysacchari...
Damasceno, Samara Rodrigues Bonfim; Rodrigues, Jocélia C.; Silva, Renan O.; Nicolau, Lucas Antonio Duarte; Chaves, Luciano S.; Freitas, Ana L. P.Seaweeds are the most abundant source of polysaccharides such as alginates and agar, as well as carrageenans. This study aimed to investigate the gastroprotective activity and the mechanism underlying this activity of a sulfated-polysaccharide fraction extracted from the algae Hypnea musciformis (Wulfen) J.V. Lamour. (Gigartinales– Rhodophyta). Mice were treated with sulfated-polysaccharide fraction (3, 10, 30,...
Anti-inflammatory and antinociceptive activity of epiisopiloturine, an imidazol...
Silva, Valdelânia G.; Silva, Renan O.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Prudêncio, Rafael S.; Aragão, Karoline SabóiaThe aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus. The anti-inflammatory activity of 1 was evaluated using several agents that induce paw edema and peritonitis in Swiss mice. Paw tissue and peritoneal fluid samples were obtained to determine myeloperoxidase (MPO) activity or ...
Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cyt...
Silva, Renan O.; Sousa, Francisca Beatriz M.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Silva, Valdelânia G.Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and oxidative stress. The anti-inflammatory activities of phytol were assessed by measuring paw edema...
Polysaccharide isolated from Agardhiella ramosissima : chemical structure and a...
Batista, Jalles A.; Dias, Eulina G.N.; Brito, Tarcisio V.; Prudêncio, Rafael S.; Silva, Renan O.; Ribeiro, Ronaldo A.; Souza, Marcellus Henrique L.P.The sulfated polysaccharide (PLS) fraction of Agardhiella ramosissima was characterized by microanalysis, infrared spectroscopy, NMR and gas–liquid-chromatography–mass-spectrometry. The main constituent of PLS was the carrageenan. The monosaccharide composition of the PLS showed galactose, 3,6- anhydrogalactose and 6-O-methylgalactose. The PLS (30 mg kg−1) significantly reduced the paw oedema induced by carrage...