53 documents found, page 1 of 6

Evaluation of P-glycoprotein activity mediated by fiscalin derivatives at the r...

Background: P-glycoprotein (P-gp) is an active efflux pump that reduces xenobiotics’ accumulation inside cells, and which activity can be modulated by inhibitors, inducers and activators [1,2]. The first ones have been used to counteract the multidrug resistance (MDR) phenomena and the inducers and activators have been proposed as a therapeutic approach in intoxication scenarios. In fact, P-gp binds several unr...

Novel Edaravone Derivatives as Neuroprotective Agents for the Treatment of ALS

Background: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease (ND) with limited treatment options [1]. Although with some drawbacks, Edaravone is one of the available drugs for ALS that targets oxidative stress (OS), a key factor in the pathophysiology of this disease [1]. Objective: This work aimed to evaluate the cytotoxic effects and neuroprotective potential of a new series of Edaravone der...

Programas de enfermagem de reabilitação promotores da capacitação do cuidador: ...

Tornar-se cuidador inesperadamente pode ser um desafio profundo e transformador, muitas vezes exigindo que a pessoa se adapte rapidamente a uma nova realidade. Este papel, frequentemente causado por eventos críticos ou mudanças súbitas na saúde de um familiar, tem implicações emocionais, práticas e psicológicas no cuidador. O enfermeiro de reabilitação desempenha um papel crucial no apoio ao cuidador. Ele atua ...

Disclosing the antifungal mechanisms of the Cyclam Salt H4[H2(4-CF3PhCH2)2Cycla...

Mycoses are one of the major causes of morbidity/mortality among immunocompromised individuals. Considering the importance of these infections, the World Health Organization (WHO) defined a priority list of fungi for health in 2022 that include Candida albicans as belonging to the critical priority group and Pichia kudriavzevii (Candida krusei) to the medium priority group. The existence of few available antifu...

Unraveling fiscalin derivatives' interactions with P-glycoprotein: a computatio...

Background: P-glycoprotein (P-gp), a crucial efflux transporter located on the apical membrane of vital barrier tissues, plays a critical role in the detoxification of several endobiotics and xenobiotics [1,2]. Notably, fiscalin derivatives exhibit diverse interactions with P-gp, demonstrating inhibitory or activating effects. This interaction leads to a reduction or increase in the transported substrate levels...

Synergistic anti-bacterial activity of imidazole-based azo dyes with polyvinylp...

The high demand for novel antimicrobial textiles by the medical, healthcare, hygiene, sportswear, personal protective equipment, and filtration sectors promoted the growth of functional textiles. However, the efficacy of antimicrobial agents against different pathogens is a considerable challenge due to the distinctive mechanisms of action and resistance. The development of novel synergistic antimicrobial dyes ...

Halochromic silk fabric as a reversible pH-sensor based on a novel 2-aminoimida...

Textiles are important components for the development of lightweight and flexible displays useful in smart materials. In particular, halochromic textiles are fibrous materials with a color-changing ability triggered by pH variations mainly based on pH-sensitive dye molecules. Recently, a novel class of 2-aminoimidazole azo dyes was developed with distinct substituent patterns. In this work, silk fabric was func...

Synergistic antimicrobial activity of silver nanoparticles with an emergent cla...

he combination of two or more agents capable of acting in synergy has been reported as a valuable tool to fight against pathogens. Silver nanoparticles (AgNPs) present a strong antimicrobial action, although their cytotoxicity for healthy cells at active concentrations is a major concern. Azoimidazole moieties exhibit interesting bioactivities, including antimicrobial activity. In this work, a class of recently...

Red-shifted and pH-responsive imidazole-based Azo Dyes with potent antimicrobia...

A novel route is described to obtain 2 aminoimidazole azo dyes with unique substituents pattern in the heteroaryl unit that provides halochromic properties, exhibiting vibrant colours that change from magenta to deep blue. Potent antimicrobial properties against infectious yeasts were demonstrated. No cytotoxicity was detected for concentrations lower than 16 μg·mL-1

CConjugating azoimidazoles and gold nanoparticles for a synergistic antimicrobi...