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Evaluation of P-glycoprotein activity mediated by fiscalin derivatives at the r...
Moreira, Beatriz; Sousa, Pedro; Silva, Nuno; Milhazes, Nuno; Silva, Renata; Remião, Fernando; Sousa, Maria Emília; Rocha-Pereira, CarolinaBackground: P-glycoprotein (P-gp) is an active efflux pump that reduces xenobiotics’ accumulation inside cells, and which activity can be modulated by inhibitors, inducers and activators [1,2]. The first ones have been used to counteract the multidrug resistance (MDR) phenomena and the inducers and activators have been proposed as a therapeutic approach in intoxication scenarios. In fact, P-gp binds several unr...
Unveiling the neuroprotective potential of new xanthene derivatives in Parkinso...
Azevedo , Rita; Costa , Inês; Maia , Miguel; Martins , Márcia; Remião , Fernando; Sousa, Maria Emília; Silva , RenataBackground: Parkinson's disease (PD) is a neurodegenerative condition marked by the premature loss of dopaminergic neurons in the substantia nigra pars compacta. Additionally, PD is linked to several neuropathological processes, such as the formation of Lewy bodies, neuroinflammation, mitochondrial dysfunction, ferroptosis and oxidative stress [1-4]. Despite the notable progress in PD research, the development ...
FLOW CYTOMETRIC EVALUATION OF PERIPHERAL BLOOD BIOMARKERS FOR SOLID TUMOURS IMM...
Trigo, Ana Catrina; Maia, Patrícia; Godinho, Inês; Rodrigues, Catarina A.; Sousa, Maria Emília; Pires, Ana Marta; Azevedo, Carla; Santos, Lúcio LaraCancer treatment is an area that is constantly being updated, namely with the discovery of immunotherapy as a clinically effective therapeutic modality for various types of cancer. Among these innovative therapies, immune checkpoint inhibitors (ICI) have proven to provide significant and long-lasting responses. However, this response does not occur for all patients, i.e., some patients do not benefit from this ...
11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic C...
Sousa, Maria Emília; Araújo, Maria João; do Vale, Maria Luísa; Andrade, Paula B; Branco, Paula Sério; Gomes, Paula; Moreira, RuiFor the first time under the auspices of Sociedade Portuguesa de Química, the competences of two important fields of Chemistry are brought together into a single event, the 11st National Organic Chemistry Meeting and the the 4th National Medicinal Chemistry Meeting, to highlight complementarities and to promote new synergies. Abstracts of plenary lectures, oral communications, and posters presented during the m...
Multidrug resistance reversal effects of aminated thioxanthones and interaction...
Palmeira, Andreia; Sousa, Maria Emília; Fernandes, Miguel X.; Pinto, Madalena M.; Vasconcelos, M. HelenaAminated thioxanthones have recently been described as dual-acting agents: growth inhibitors of leukemia cell lines and P-glycoprotein (P-gp) inhibitors. To evaluate the selectivity profile of thioxanthones as inhibitors of multidrug resistance (MDR), their interaction with other ABC transporters, which were found to have a strong correlation with multidrug resistance, such as multidrug resistant proteins 1 (MR...