88 documents found, page 1 of 9
The preponderance of public policies in the realisation of the Sustainable Deve...
Silva, Rita; Lira, Miguel; Costa, Júlio; Conde, FátimaPurpose: This study aims to expose the importance of sustainable local development in creating favourable conditions for the community in general.Methodology: A qualitative study was carried out, involving two phases: conducting interviews, and document analysis.Results: The implementation of the SDGs leads to an increase in spending, so municipalities must be aware of this fact and make savings in other areas ...
A first-in-class inhibitor of homologous recombination DNA repair counteracts t...
Calheiros, Juliana; Silva, Rita; Barbosa, Filipa; Morais, João; Moura, Sara Reis; Almeida, Sofia; Fiorini, Elena; Mulhovo, Silva; Aguiar, Tatiana QuintaBackground Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib. Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resistant to DNA-targeting agents like olaparib, restraining their clinical application. Recently, we disclosed a m...
Quando a Terra treme
Silva, RitaO arquipélago dos Açores está localizado numa região muito particular, onde as placas tectónicas Norte-Americana, Eurasiática e Africana se contactam, definindo um ponto de intersecção designado por Junção Tripla dos Açores. As placas tectónicas são grandes blocos de rocha rígida que correspondem à camada superficial da terra. Elas movimentam-se tão lentamente que não damos por isso e com diferentes velocidades...
Comunicar o turismo em Portugal pós-pandemia
Silva, RitaThis article explores the complexity of communicating tourism in Portugal after the pandemic, considering the significant impacts of the health crisis on the sector. An analysis is made of the communication of tourism entities in Portugal in the pre-pandemic and post-pandemic period, outlining how the arrival of COVID-19 has forced hotel chains to adjust communication strategies in order to regain the trust of ...
A adoção dos Objetivos de Desenvolvimento Sustentável no Governo Local Portuguê...
Costa, Júlio; Silva, Rita; Conde, Fátima; Lira, MiguelObjetivo: No caminho da sustentabilidade, os municípios ocupam uma posição privilegiada para influenciar a mudança de mentalidades, dada a sua proximidade com as comunidades. O propósito deste estudo é reforçar a importância da implementação dos Objetivos de Desenvolvimento Sustentável (ODS) a nível local, efetuando uma análise comparativa das atividades sustentáveis realizadas nos municípios da Covilhã e de So...
DIAGNOSTIC APPROACH TO ARTERIAL HYPERTENSION OF SUSPECTED SECONDARY CAUSE IN PR...
Silva, Rita; Mateus-Pinheiro, António; Carreira, Ana; Coutinho-Teixeira, Vítor; Ferreira, RogérioRenal pathology is one of the leading causes of secondary arterial hypertension. Hypertension of a renal cause can originate in the renal parenchyma or the renal artery and is called renal parenchymal hypertension or renovascular hypertension, respectively. The presence of hypertension is common in kidney diseases, being a critical prognostic factor, so its diagnosis, treatment and adequate guidance are essenti...
DIAGNOSTIC APPROACH TO ARTERIAL HYPERTENSION OF SUSPECTED SECONDARY CAUSE IN PR...
Mateus-Pinheiro, António; Carreira, Ana; Silva, Rita; Coutinho-Teixeira, Vítor; Ferreira, RogérioSecondary Arterial Hypertension (AHT) is responsible for 5 to 10% of all cases of AHT and presents increased morbimortality when compared to primary AHT. Secondary AHT stems from a diverse group of medical conditions, which are potentially reversible, or even curable, through specific management approaches. The potential to effectively reverse this group of diseases and, by consequence, the associated AHT accou...
DIAGNOSTIC APPROACH TO ARTERIAL HYPERTENSION OF SUSPECTED SECONDARY CAUSE IN PR...
Carreira, Ana; Mateus-Pinheiro, António; Silva, Rita; Melo, Miguel; Coutinho-Teixeira, Vítor; Ferreira, RogérioEndocrine diseases are frequent causes of secondary hypertension, and primary hyperaldosteronism is the most common endocrine cause of hypertension. Unlike other endocrine diseases, primary hyperaldosteronism has no typical phenotypic characteristics, and is often misdiagnosed as essential hypertension. It is, however, associated with much higher morbidity and mortality than essential hypertension. Targeted the...
Rasmussen’s Syndrome: Case-Series Study from a Refractory Epilepsy Reference Ce...
Serôdio, Miguel; Pires, Marcela; Azurara, Laura; Santos, Alexandra; Sá, Francisca; Silva, Rita; Canas, Nuno; Ferreira, José Carlos; Cabral, PedroIntroduction: Rasmussen’s syndrome (RS) is a rare immunomediated disease of childhood-predominant onset, presenting with refractory epilepsy and neurological deficits associated to progressive brain hemiatrophy. Its pathophysiological mechanisms are not well understood, and the effect of immunotherapy is not ascertained. Hemispheric surgery is an efficacious therapy for epilepsy, despite focal and cognitive seq...
Pode o português ser para todes? reflexões sobre o uso de linguagem neutra
Silva, RitaO debate sobre o binarismo de género caraterístico de certas línguas não é recente, mas só nos últimos anos se tem testemunhado um maior empenho na criação de uma linguagem neutra em género. Esta neolinguagem ou linguagem não-binária, cujo usou se popularizou sobretudo na internet, surge como uma alternativa às formas existentes, procurando incluir as várias identidades de género mediante a utilização de um dis...