13 documents found, page 1 of 2

Unconjugated bilirubin differentially affects the redox status of neuronal and ...

We investigated whether nerve cell damage by unconjugated bilirubin (UCB) is mediated by oxidative stress and ascertained the neuronal and astroglial susceptibility to injury. Several oxidative stress biomarkers and cell death were determined following in

Bilirubin injury to neurons: contribution of oxidative stress and rescue by gly...

It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central nervous system, and oxidative stress is emerging as a relevant event in the mechanisms of UCB encephalopathy. In contrast, the hydrophilic bile acid, ursod

Apoptosis and impairment of neurite network by short exposure of immature rat c...

Nerve cell injury induced by unconjugated bilirubin (UCB) has been implicated in brain damage during severe neonatal hyperbilirubinemia, although the molecular mechanisms underlying UCB neurotoxicity are still not clarified. It has been suggested recently

Astrocytes modulate neuronal injury during hyperbilirubinemia

Profile of early microglial activation by unconjugated bilirubin

Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cor...

The pathogenesis of bilirubin encephalopathy seems to result from accumulation of unconjugated bilirubin (UCB) within the brain. We have recently demonstrated that UCB causes astroglial release of proinflammatory cytokines and glutamate, as well as cell d

MAPKs are key players in mediating cytokine release and cell death induced by u...

When activated by unconjugated bilirubin (UCB), astrocytes are important sources of inflammatory mediators such as TNF-alpha, IL-1 beta and IL-6, which may contribute for the neurotoxicity observed during severe neonatal hyperbilirubinemia. In the present

Cellular mechanisms underlying dysfunction of immature neurons by hyperbilirubi...

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astroc...

Hypoxia-ischemia in the perinatal period is a common cause of neurologic disability in children and is often associated with neonatal morbidity and mortality. Another frequent condition of the newborn is hyperbilirubinemia and it is well known that deposi

Roles of amyloid beta-peptide-associated oxidative stress and proteomics-identi...