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Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mor...

Alahmad, B; Khraishah, H; Royé, D; Vicedo-Cabrera, AM; Guo, Y; Papatheodorou, SI; Achilleos, S; Acquaotta, F; Armstrong, B; Bell, ML; Pan, SC

Background: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Coll...


The Dysfunctional Immune System in Common Variable Immunodeficiency Increases t...

Gullo, I; Costa, C; Silva, SL; Ferreira, C; Motta, A; Silva, SP; Ferreira, RD; Rosmaninho, P; Faria, E; Costa, JTd; Câmara, R; Gonçalves, G

Gastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...


Protecting animals and enabling research in the European Union: an overview of ...

Olsson, IAS; Silva, SP; Townend, D; Sandøe, P

In 1986, European Directive 86/609/EEC, regulating the use of animals in research, was one of the first examples of common legislation to set standards for animal protection across the Member States of the former European Economic Community (EEC), now the European Union (EU), with the aim of securing a level European playing field. Starting in 2002, a process of revising European animal experimentation legislat...


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