3 documents found, page 1 of 1
Centrosome amplification in chondrosarcomas: A primary cell culture and cryopre...
Pinheiro, Carla Aparecida; Soares, Iberê Cauduro; Penna, Valter; Squire, Jeremy; Reis, R. M.; Silva, Sandra Regina Morini da; Carvalho, Isabela deThe genetics background underlying the aggressiveness of chondrosarcoma (CS) is poorly understood. One possible cause of malignant transformation is chromosomal instability, which involves an error in mitotic segregation due to numerical and/or functional abnormalities of centrosomes. The present study aimed to evaluate centrosome amplification in cryopreserved samples of tumor tissue from patients with CS. An ...
Ki-67 and CD100 immunohistochemical expression is associated with local recurre...
Campos, Marcelo; Campos, Sivana Gisele Pegorin de; Ribeiro, Guilherme Gomes; Eguchi, Flávia Coltri; Silva, Sandra Regina Morini daSoft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistance to adjuvant therapies have been reported. Metastases are commonly identified in STS patients during diagnosis and the...
MET Is highly expressed in advanced stages of colorectal cancer and indicates w...
Oliveira, Antônio Talvane Torres; Matos, Delcio; Logullo, Angela Flavio; Silva, Sandra Regina Morini da; Neto, Ricardo ArtigianiThe aim of the present study was to evaluate by immunohistochemistry the prognostic meaning of the tumor marker MET (hepatocyte growth factor) in patients submitted to surgical resection due to primary colorectal adenocarcinoma. PATIENTS AND METHODS: A retrospective study was carried out that included 286 consecutive patients with colorectal adenocarcinoma, submitted to surgical resection at Barretos Cancer Hos...