2 documents found, page 1 of 1
The dysfunctional immune system in common variable immunodeficiency increases t...
Gullo, Irene; Costa, Catarina; Silva, Susana L.; Ferreira, Cristina; Motta, Adriana; Silva, Sara P.; Duarte Ferreira, Ruben; Rosmaninho, PedroGastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...
Monozygotic twins concordant for common variable immunodeficiency : strikingly ...
Silva, Susana L.; Fonseca, Mariana; Pereira, Marcelo L. M.; Silva, Sara P.; Barbosa, Rita R.; Serra-Caetano, Ana; Blanco, Elena; Rosmaninho, PedroMonozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and genetic heterogeneity, with monogenic transmission accounting for only a minority of the cases. Here, we report a ...