21 documents found, page 1 of 3
3D bioactive ionic liquid-based architectures: an anti-inflammatory approach fo...
Gomes, Joana M.; Marques, Ana Catarina Fernandes; Rodrigues, Luísa Cidália Guimarães; Silva, Tiago H.; Silva, Simone S.; Reis, R. L.3D bioprinting enables the fabrication of biomimetic cell-laden constructs for cartilage regeneration, of- fering exclusive strategies for precise pharmacological screenings in osteoarthritis (OA). Synovial inflam- mation plays a crucial role in OAâ s early stage and progression, characterized by the increased of the syn- ovial pro-inflammatory mediators and cytokines and chondrocyte apoptosis. Therefore, there...
Chitosan-based hierarchical scaffolds crosslinked with genipin
Piaia, Lya; Silva, Simone S.; Fernandes, Emanuel Mouta; Gomes, Joana M.; Franco, Albina Ribeiro; Leonor, I. B.; Fredel, Márcio C.; Salmoria, Gean V.Osteochondral defects present significant challenges for effective tissue regeneration due to the complex composition of bone and cartilage. To address this challenge, this study presents the fabrication of hierarchical scaffolds combining chitosan/β-tricalcium phosphate (β-TCP) to simulate a bone-like layer, interconnected with a silk fibroin layer to mimic cartilage, thus replicating the cartilage-like laye...
Tunable silk matrices using ionic liquids and their biomedical applications
Silva, Simone S.; Gomes, Joana M.; Kundu, Subhas C; Reis, R. L.Silk fibroin (SF) is a well-known natural protein with considerable potential to develop high-value materials for biomedical applications due to its intrinsic features, such as availability, versatility, and biocompatibility. In recent investigations, ionic liquids (ILs) have attracted attention as green solvents for tuning SF-based biomaterials. Like traditional solvents, ILs can be used as a solvent to proces...
Sulfated seaweed polysaccharides
Inácio, Ana Rita Matos; Carvalho, Ana C.; Oliveira, Catarina; Reys, Lara Priscila Lopes; Silva, Simone S.; Neves, N. M.; Martins, Albino; Reis, R. L.Mankind has used natural resources for many different applications, from food and clothes to drugs, but only recently is giving the due attention to the need for a responsible management of these resources toward sustainability. One of the approaches is to take the most out of its resources, addressing the several components of natural resources, which can be used in many industrial fields. In this regard, many...
Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue eng...
Piaia, Lya; Silva, Simone S.; Gomes, Joana M.; Franco, Albina Ribeiro; Fernandes, Emanuel Mouta; Lobo, Flávia Cristina Marques; Rodrigues, Luísa C.Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable...
Fucoidan-based hydrogels particles as versatile carriers for diabetes treatment...
Reys, Lara L.; Silva, Simone S.; Soares da Costa, Diana; Reis, R. L.; Silva, Tiago H.There is a current lack of fully efficient therapies for diabetes mel-litus, a chronic disease where the metabolism of blood glucose isseverely hindered by a deficit in insulin or cell resistance to thishormone. Therefore, it is crucial to develop new therapeutic strat-egies to treat this disease, including devices for the controlleddelivery of insulin or encapsulation of insulin-producing cells. Inthis work, f...
Tailoring natural-based oleogels combining ethylcellulose and virgin coconut oil
Silva, Simone S.; Rodrigues, Luísa C.; Fernandes, Emanuel M.; Lobo, Flávia C. M.; Gomes, Joana M.; Reis, R. L.Oleogels are becoming an attractive research field, since they have recently been shown to be feasible for the food and pharmaceutical sectors and provided some insights into the biomedical area. In this work, edible oleogels were tailored through the combination of ethylcellulose (EC), a gelling agent, with virgin coconut oil (VCO), vegetable oil derived from coconut. The influence of the different EC and VCO ...
Challenges and opportunities on vegetable oils derived systems for biomedical a...
Ribeiro, Ana R.; Silva, Simone S.; Reis, R. L.Vegetable oils have been suggested in polymer science as an environmentally friendly feedstock existing in abundance in nature, with worldwide availability and low cost. Although they have been widely explored as building blocks for polymers synthesis, their functional roles as owners of potent biomolecules are less unexplored. Their ancient biomolecules support natural biological roles such as antioxidant, ant...
Green solvents combined with bioactive compounds as delivery systems: present s...
Silva, Simone S.; Gomes, Joana M.; Reis, R. L.; Kundu, Subhas CGreen solvents such as ionic liquids (ILs) unlock possibilities for developing innovative biomedical and pharmaceutical solutions. ILs are the most investigated solvents for compound extractions, as reaction media and/or catalysts, and a desired eco-friendly solvent to process biomacromolecules for biomaterial production. Investigations demonstrate that the tunable nature and physicochemical features of ILs are...
Angiogenic potential of airbrushed fucoidan/polycaprolactone nanofibrous meshes
Reys, Lara Priscila Lopes; Silva, Simone S.; Oliveira, C.; Neves, N. M.; Martins, Albino; Reis, R. L.; Silva, Tiago H.Implantation of biomaterials and hybrid constructs in tissue engineering approaches presents major limitations such as inflammatory reaction and the lack of vasculature integration. Therefore, new strategies are needed to enhance implant function, immune protection, and revascularization. In this work, we developed fibrous meshes composed of fucoidan (Fu), a sulfated polysaccharide extracted from brown algae, a...