19 documents found, page 1 of 2
Envelhecer Ativamente em Contexto de Centro de Dia
Silva, SoraiaO presente relatório aborda o trabalho desenvolvido ao longo do estágio curricular realizado nos Centros de Dia da Santa Casa da Misericórdia de Arouca (SCMA) que decorreu entre o dia 14 de setembro de 2022 e o dia 13 de fevereiro de 2023, no âmbito do mestrado em Gerontologia Social pelo Instituto Superior de Serviço Social do Porto. De acordo com a Organização Mundial da Saúde (OMS), o envelhecimento deve ser...
Extracellular vesicles from pancreatic cancer stem cells lead an intratumor com...
Ruivo, Carolina F.; Bastos, Nuno; Adem, Barbara; Batista, Ines; Duraes, Cecilia; Melo, Carlos A.; Castaldo, Stephanie A.; Campos‐Laborie, FranciscoObjective: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour. Design: We have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). To determine th...
Oncological Pathology at Home: One Year of Experience
Mariano, Paula; Silva, Soraia; Calmeiro, Maria Eufémia; Antunes, Isabel; André, Maria EugéniaIntroduction: Neoplasia is considered the second disease with the highest morbidity and mortality. Hospital-level care is often unavoidable. The objective of Home Hospitalization (HH) is to minimize hospital complications and provide greater satisfaction to the patient and family/caregiver. Material and Methods: This article reports one year of HH experience at the Unidade Local de Saúde of Castelo Branco with ...
Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro...
Silva, Soraia; Bicker, Joana; Fonseca, Carla; Ferreira, Nuno R.; Vitorino, Carla; Alves, Gilberto; Falcão, Amílcar; Fortuna, AnaDepression is a common mental disorder. Its treatment with selective serotonin reuptake inhibitors (SSRIs) is effective only in a fraction of patients, and pharmacoresistance is increasing steadily. Intranasal (IN) drug delivery to the brain stands out as a promising strategy to improve current therapeutic approaches by operating as a shuttle to overcome the blood-brain barrier. This work aimed to simultaneousl...
Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction...
Silva, Soraia; Bicker, Joana; Falcão, Amílcar; Fortuna, AnaScientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics has highlighted the importance of drug dosing-time. Circadian oscillations alter drug absorption, distribution, metabolism, and excretion (ADME) as well as intracellular signaling systems, target molecules (e.g., receptors, transporters, and enzymes), and gene transcription. Although several antidepressant drugs are clinical...
QbD-driven development of intranasal lipid nanoparticles for depression treatment
Vitorino, Carla; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Ferreira, Amílcar Celta Falcão Ramos; Fortuna, Ana Cristina BairradaDepression is a life-threatening psychiatric disorder and a multifactorial global public health concern. Current pharmacological treatments present limited efficacy, and are associated with several harmful side effects and development of pharmacoresistance mechanisms. Developing more effective therapeutic options is therefore a priority. This work aims at efficiently designing an antidepressant therapeutic surr...
Downscale fermentation for xylooligosaccharides production by recombinant Bacil...
Amorim, Cláudia; Silvério, Sara C.; Gonçalves, Raquel F. S.; Pinheiro, Ana Cristina; Silva, Soraia; Coelho, Elisabete; Coimbra, Manuel A.The global demand of prebiotics such as xylooligosaccharides (XOS) has been growing over the years, motivating the search for different production processes with increased efficiency. In this study, a cloned Bacillus subtilis 3610, containing the xylanase gene xyn2 of Trichoderma reesei coupled with an endogenous secretion tag, was selected for XOS production through direct fermentation of beechwood xylan. A mi...
Bio-electrospraying of chondrocytes for cartilage tissue enginnering applications
Semitela, Ângela; Ramalho, Gonçalo; Sousa, Cátia; Silva, Soraia; Marques, Paula A.A.P.; Mendes, Alexandrina F.; Completo, AntónioSem resumo disponível.
Electrosprayed cells proliferative behaviour in a 3d microporous scaffold
Ramalho, Gonçalo; Semitela, Ângela; Sousa, Cátia; Silva, Soraia; Marques, Paula A.A.P.; Mendes, Alexandrina F.; Completo, AntónioSem resumo disponível.
Chondrocytes electrospraying: parameters optimization towards in situ cell lade...
Ramalho, Gonçalo; Semitela, Ângela; Sousa, Cátia; Silva, Soraia; Marques, Paula A.A.P.; Completo, AntónioCartilage tissue engineering (TE) is offering suitable therapeutic solutions for articular cartilage degenerative diseases, such as osteoarthritis, a big problem in contemporary society. TE is able to combine biomaterials and cells to create biomimetic scaffolds, that can mimic the depth dependent nanostructural organization of the fibrous collagen network of the native articular cartilage. This work uses the c...