7 documents found, page 1 of 1
The dysfunctional immune system in common variable immunodeficiency increases t...
Gullo, Irene; Costa, Catarina; Silva, Susana L.; Ferreira, Cristina; Motta, Adriana; Silva, Sara P.; Duarte Ferreira, Ruben; Rosmaninho, PedroGastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...
Monozygotic twins concordant for common variable immunodeficiency : strikingly ...
Silva, Susana L.; Fonseca, Mariana; Pereira, Marcelo L. M.; Silva, Sara P.; Barbosa, Rita R.; Serra-Caetano, Ana; Blanco, Elena; Rosmaninho, PedroMonozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and genetic heterogeneity, with monogenic transmission accounting for only a minority of the cases. Here, we report a ...
Major CD4 T-cell depletion and immune senescence in a patient with chronic gran...
Albuquerque, Adriana S.; Fernandes, Susana M.; Tendeiro, Rita; Cheynier, Rémi; Lucas, Margarida; Silva, Susana L.; Victorino, Rui M. M.; Sousa, Ana E.Chronic granulomatous disease (CGD) results from primary defects in phagocytic reactive oxygen species (ROS) production. T-cell evaluation is usually neglected during patients' follow-up, although T-cell depletion has been reported in CGD through unknown mechanisms. We describe here a 36-year-old patient with X-linked CGD with severe CD4 T-cell depletion <200 CD4 T-cells/μl, providing insights into the mechanis...
IL-7-induced proliferation of human naive CD4 T-cells relies on continued thymi...
Silva, Susana L.; Albuquerque, Adriana S.; Matoso, Paula; Charmeteau-de-Muylder, Bénédicte; Cheynier, Rémi; Ligeiro, Dário; Abecasis, Miguel; Anjos, RuiNaive CD4 T-cell maintenance is critical for immune competence. We investigated here the fine-tuning of homeostatic mechanisms of the naive compartment to counteract the loss of de novo CD4 T-cell generation. Adults thymectomized in early childhood during corrective cardiac surgery were grouped based on presence or absence of thymopoiesis and compared with age-matched controls. We found that the preservation of...
Autoimmunity and allergy control in adults submitted to complete thymectomy ear...
Silva, Susana L.; Albuquerque, Adriana; Amaral, Andreia J.; Li, Quan-Zhen; Mota, Catarina; Cheynier, Rémi; Victorino, Rui M. M.The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels, to exclude thymic rebound and/or ectopic thymuses. In agreement, they featured severe naïv...
Human naïve regulatory T-cells feature high steady-state turnover and are maint...
Silva, Susana L.; Albuquerque, Adriana S.; Serra-Caetano, Ana; Foxall, Russell B.; Pires, Ana R.; Matoso, Paula; Fernandes, Susana M.; Ferreira, JoãoNaïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution remain unclear. We found that in adults thymectomized early in infancy the naïve-Treg pool is remarkably well pre...
Projeto sincronias : uma experiência de integração
Silva, Susana L.; Campos, Carlos; Silva, Elisabete; Morais, Ana; Campos, Filipa; Almeida, Raquel; Santos, Teresa; Marques, AntónioVários autores e entidades internacionais de referência têm determinado em documentos orientadores para os cuidados de psiquiatria e reabilitação psicossocial a pessoas com experiência de doença mental, a utilização de atividades artísticas como boa prática, já com alguma evidência, na promoção do recovery, participação social e qualidade de vida. O projeto Sincronias, resultante da parceria estabelecida entre ...