56 documents found, page 1 of 6

Recovery after exploitation of stalked barnacles is facilitated by the presence...

We have followed the recovery of gaps produced either by harvesters or by scientists in stands of stalked barnacle (Pollicipes pollicipes) during two years in four regions of Europe (SW Portugal, Galicia and Asturias in Spain and Brittany in France; n = 423 gaps), which was extended to four years in Asturias (n = 252 gaps). The presence of adult conspecifics in the margins of the gaps increased by at least four...

An acclimatization period in a cage promotes site fidelity of hatchery-reared d...

The influence of an in-situ acclimatization period of five weeks, seeking the settlement and fidelity of hatchery-reared dusky groupers (Epinephelus marginatus) to the release sites in restocking actions, was tested using acoustic biotelemetry. Eight tagged adult groupers were submitted to the wild conditions in a fish farm cage, while seven remained in the hatchery and tagging location until they were all rele...

Characterization of novel double-reporter strains of Mycobacterium abscessus fo...

Mycobacterium abscessus (Mab) is an emerging pathogen that poses a severe health threat, especially in people with cystic fibrosis and other chronic lung diseases. Available drugs are largely ineffective due to an exquisite intrinsic resistance, making Mab infections only comparable to multidrug-resistant tuberculosis. Current treatment is based on lengthy multidrug therapy, complicated by poor outcomes and hig...

Factors associated with patient delay in the diagnosis of TB – a study of healt...

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Mycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. Treatments are extremely ineffective and based on a multi-drug regimen, resulting in low patient compliance. Consequently, the scientific community is urged to identify new and effective drugs to treat these infections. One of the strategies employed to this en...

Delays have dangerous ends: Tuberculosis diagnosis delay in Portugal, a qualita...

A large‑scale comparison of reproduction and recruitment of the stalked barnacl...

Understanding large-scale spatial and temporal patterns of marine populations is a central goal in ecology, which has received renewed attention under climate change. However, few studies explore the large-scale dynamics of populations using standardized protocols and during the same time frames. We studied the phenology and intensity of reproduction and recruitment for the intertidal stalked barnacle Pollicipe...

Catálogo da exposição “Áreas Marinhas Protegidas da Costa Sudoeste”

Catálogo da exposição “Áreas Marinhas Protegidas da Costa Sudoeste”.

Improving the Antimycobacterial Drug Clofazimine through Formation of Organic S...

This work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin. Organic salts derived from active pharmaceutical ingredients (API-OSs), as those herein disclosed, hold promise as cost-effective formulations with improved fea...

Serum amyloid A proteins reduce bone mass during mycobacterial infections

IntroductionOsteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. MethodsGenetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healt...