2 documents found, page 1 of 1
Análise do efeito de polimorfismos não-sinônimos em genes de reparo de DNA da v...
Silva, Thayse Azevedo daConselho Nacional de Desenvolvimento Científico e Tecnológico; In vitro and in animal models, APE1, OGG1, and PARP-1 have been proposed as being involved with inflammatory response. In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis and also developed a system to enable the functional analysis of polymorphic proteins. Patients with ba...
Helicobacter pylori genotype and polymorphisms in DNA repair enzymes : where do...
Silva-Fernandes, Isabelle Joyce de Lima; Silva, Thayse Azevedo da; Agnez-Lima, Lucymara Fassarella; Ferreira, Márcia Valéria PitomveiraOne of the mechanisms proposed by which H. pylori causes gastric cancer (GC) is through DNA damage due to chronic inflammation. Genomic integrity is guaranteed by repair enzymes such as APE-1, OGG-1, and PARP-1. Host genetic polymorphisms associated with the bacterial strain may influence the ability to repair the damage, contributing to the development of H. pylori-associated GC. The aim of this study was to d...