101 documents found, page 1 of 11
3D-printed cell-instructive scaffolds based on Chondrosia reniformis collagen a...
Rocha, Miguel Soares; Marques, Ana Catarina Fernandes; Pina, Sandra Cristina Almeida; Oliveira, Joaquim M.; Reis, R. L.; Silva, Tiago H.Bone defects pose a global concern due to their high prevalence. Despite the significant advances in the development of novel therapies and sustainable biomaterial solutions, these still do not perfectly address the clinical needs, in particular, the paradigm shift of personalized treatments. In this sense, marine-origin materials allied to three-dimensional (3D) printing are arising as a feasible alternative t...
How significant are marine invertebrate collagens? Exploring trends in research...
Almeida, M.; Silva, Tiago H.; Solstad, R. G.; Lillebo, A. I.; Calado, R.; Vieira, H.This review is focused on the research, innovation and technological breakthroughs on marine invertebrate collagens and their applications. The findings reveal that research dates back to the 1970s, and after a period of reduced activity, interest in collagens from several marine invertebrate groups was renewed around 2008, likely driven by the increased commercial interest in these biomolecules of marine origi...
The characterization and cytotoxic evaluation of chondrosia reniformis collagen...
Rocha, Miguel S.; Marques, Catarina F.; Carvalho, Ana C.; Martins, Eva; Ereskovsky, Alexander; Reis, Rui L.; Silva, Tiago H.Chondrosia reniformis is a collagen-rich marine sponge that is considered a sustainable and viable option for producing an alternative to mammalian-origin collagens. However, there is a lack of knowledge regarding the properties of collagen isolated from different sponge parts, namely the outer region, or cortex, (ectosome) and the inner region (choanosome), and how it affects the development of biomaterials. I...
Biomateriais e Medicina Regenerativa: o papel do I3Bs numa estratégia de susten...
Silva, Tiago H.; Almeida, Mariana; Peixoto, Daniela; Fernandes, Emanuel Mouta; Alves, N. M.; Reis, R. L.[Excerto] O Instituto de Investigação em Biomateriais, Biodegradáveis e Biomiméticos, I3Bs, é a mais recente Unidade Orgânica da Universidade do Minho, surgindo em março de 2018, tendo sido uma das primeiras Unidades Orgânicas de Investigação criada no âmbito do RJIES (2007) em Universidades públicas Portuguesas. No entanto, a sua história tem origem em 1999, com a criação do Grupo de Investigação 3B’s, dedicad...
3D bioactive ionic liquid-based architectures: an anti-inflammatory approach fo...
Gomes, Joana M.; Marques, Ana Catarina Fernandes; Rodrigues, Luísa Cidália Guimarães; Silva, Tiago H.; Silva, Simone S.; Reis, R. L.3D bioprinting enables the fabrication of biomimetic cell-laden constructs for cartilage regeneration, of- fering exclusive strategies for precise pharmacological screenings in osteoarthritis (OA). Synovial inflam- mation plays a crucial role in OAâ s early stage and progression, characterized by the increased of the syn- ovial pro-inflammatory mediators and cytokines and chondrocyte apoptosis. Therefore, there...
The characterization and cytotoxic evaluation of Chondrosia reniformis collagen...
Rocha, Miguel Soares; Marques, Ana Catarina Fernandes; Carvalho, Ana Cristina Pontes; Martins, Eva; Ereskovsky, Alexander; Reis, R. L.; Silva, Tiago H.Chondrosia reniformis is a collagen-rich marine sponge that is considered a sustainable and viable option for producing an alternative to mammalian-origin collagens. However, there is a lack of knowledge regarding the properties of collagen isolated from different sponge parts, namely the outer region, or cortex, (ectosome) and the inner region (choanosome), and how it affects the development of biomaterials. I...
Extraction and purification of biopolymers from marine origin sources envisagin...
Carvalho, Duarte Nuno; Gonçalves, Cristiana; Sousa, Rita Alexandra Oliveira; Reis, R. L.; Oliveira, Joaquim M.; Silva, Tiago H.Biopolymers are a versatile and diverse class of materials that has won high interest due to their potential application in several sectors of the economy, such as cosmetics, medical materials/devices, and food additives. In the last years, the search for these compounds has explored a wider range of marine organisms that have proven to be a great alternative to mammal sources for these applications and benefit...
Marine sponges and derived biopolymers for regenerative medicine
Rocha, Miguel Soares; Reis, R. L.; Silva, Tiago H.Marine sponges possess structural materials and morphological features that make them an ideal source for biomimetic design and development of biomaterials for tissue engineering and regenerative medicine (TERM) applications. This chapter highlights the latest advancements in the application of sponge-mimetic biomaterials in biomedical applications, with a particular focus on bone tissue engineering. This chapt...
From its nature to its function: marine-collagen-based-biomaterials for hard ti...
Carlos, Gabriela Soares Diogo; Pirraco, Rogério P.; Reis, R. L.; Silva, Tiago H.Rapidly growing demand for collagen-based therapeutic applications requires a great amount of collagen stock. Commercial collagen is mainly confined to mammalian sources, which have concerns about zoonotic disease transfer and, additionally, the problem of terrestrial animals' overexploitation, which, even so, does not meet the crescent demand for collagen. The extraction of collagen from marine organisms, incl...
Marine gelatin-methacryloyl-based hydrogels as cell templates for cartilage tis...
Machado, Inês; Marques, Catarina F.; Martins, Eva; Alves, Ana L.; Reis, Rui L.; Silva, Tiago H.Marine-origin gelatin has been increasingly used as a safe alternative to bovine and porcine ones due to their structural similarity, avoiding the health-related problems and sociocultural concerns associated with using mammalian-origin materials. Another benefit of marine-origin gelatin is that it can be produced from fish processing-products enabling high production at low cost. Recent studies have demonstrat...