Infertility is recognized globally as a social disease and a growing medical condition, posing a significant challenge to modern reproductive health. Endometriosis, the third-most frequent gynecologic disorder, is one of the most common and intricate conditions that can lead to female infertility. Despite extensive research, the etiology, malignant transformation, and biological therapy of endometriosis remain ...
Introdução: A insuficiência cardíaca (IC) é uma síndrome caracterizada por sintomas (dispneia, fadiga) e sinais típicos (pressão venosa jugular aumentada, sons pulmonares, edema), com impacto na qualidade de vida (McDonagh et al., 2021). Objetivo: capacitar a pessoa para a gestão da IC. Material e métodos: o Projeto, com parecer da Comissão de Ética, tem como critérios de inclusão: internamento por IC, idade su...
Infection is one of the major issues associated with the failure of orthopedic devices, mainly due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance. Antimicrobial peptides (AMP) are a promising alternative to conventional antibiotics given their broad-spectrum of activity, low propensity to induce bacterial resistance, and ability to modulate host immune responses. Dhva...
In Pinhal Novo, Palmela, and neighboring municipalities, southern Lisbon region, there are a great number of small adobe masonry dwellings, made in the first half of the twentieth century. The vernacular dwellings were constructed by families that came from the north/center region of Portugal to work at the local manors and were called Caramel´s. Adobe samples from three of these dwellings were collected in Pin...
A Insuficiência Cardíaca (IC) afeta 26 milhões de pessoas, com custos elevados devido à redução da qualidade de vida, aumento do sofrimento e mortalidade. A evidência científica realça que programas de capacitação e reabilitação cardiovascular diminuem hospitalizações (Fonseca 2018). Capacitar a pessoa para a gestão da IC (Geral), aumentar a literacia em saúde, implementar um plano educacional e de reabilitação...
Introduction: Remote monitoring (RM) is a safe and effective alternative to in-office conventional follow-up. Objective: We aimed to evaluate patient satisfaction with RM and its impact on healthcare resources in a population with cardiac implantable electronic devices. Methods: Randomized, pragmatic, open-label controlled trial, with adult wearers of implantable cardioverter-defibrillator (ICD) or cardiac resy...
The COVID-19 pandemic resulted in severe, unprecedented changes affecting the world population. Restrictions in mobility, social distancing measures, and the persistent social alarm, during the first period of pandemic, resulted in dramatic lifestyle changes and affected physical and psychological wellbeing on a global scale. An international research team was constituted to develop a study involving different ...
Objectives: To compare the 12-month retention rate, effectiveness and tolerability of perampanel (PER) as a first or late add-on treatment in adult patients with focal-onset seizures (FOS), including focal to bilateral tonic-clonic seizures (FBTCS). Methods: This retrospective, observational, multicenter study was carried out in patients with FOS that received PER as a late add-on (n = 60), after failure of > 3...
Xanthones have been suggested as prospective candidates for cancer treatment. 1,2-dihydroxyxanthone (1,2-DHX) is known to interfere with the growth of several cancer cell lines. We investigated the effects of 1,2-DHX on the growth of the A375-C5 melanoma cell line and THP-1 human macrophage activity. 1,2-DHX showed a moderate growth inhibition of A375-C5 melanoma cells (concentration that causes a 50% inhibitio...