3 documents found, page 1 of 1
Unique tracheal fluid microRNA signature predicts response to FETO in patients ...
Terra, Patrícia Daniela Pereira; Deprest, Jan A.; Kholdebarin, Ramin; Khoshgoo, Naghmeh; DeKoninck, Philip; Munck, Anne A. Boerema-De; Wang, JinxiaOBJECTIVE AND BACKGROUND: Our objective was to determine the fetal in vivo microRNA signature in hypoplastic lungs of human fetuses with severe isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetuses undergoing fetoscopic endoluminal tracheal occlusion (FETO) to reverse severe lung hypoplasia due to CDH. METHODS:: We profiled microRNA expression in prenatal human lun...
Ghrelin expression in human and rat fetal lungs and the effect of ghrelin admin...
Santos, Marta; Bastos, Pedro; Gonzaga, Silvia; Roriz, José-Mário; Baptista, Maria J.; Silva, Cristina Isabel Nogueira; Rocha, Gustavo Filipe Melo AlvesGhrelin is a strong physiologic growth hormone secretagogue that exhibits endocrine and non-endocrine actions. In this study, ghrelin expression in humans and rats was evaluated throughout development of normal and hypoplastic lungs associated with congenital diaphragmatic hernia (CDH). Additionally, the effect of antenatal treatment with ghrelin in the nitrofen-induced CDH rat model was tested. In normal lungs...
Congenital diaphragmatic hernia in a patient with tetrasomy 9p
Henriques-Coelho, Tiago; Oliva-Teles, Natália; Fonseca-Silva, M. Luz; Tibboel, Dick; Guimarães, Hercília; Correia-Pinto, JorgeTetrasomy of the short arm of chromosome 9 constitutes a rare condition resulting in a well clinically recognized syndrome. In our case, in addition to the characteristic phenotype at birth, the existence of a hernia-type Bochdalek diaphragmatic defect was found. Cytogenetic analysis revealed a nonmosaic case of an isochromosome of the entire short arm of chromosome 9 with no involvement of the heterochromatic ...