8 documents found, page 1 of 1
Estudo químico e atividades antiproliferativa, tripanocida e leishmanicida de M...
Almeida,Thiago L. de; Monteiro,Josiane A.; Lopes,Greice K. P.; Chiavelli,Lucas U. R.; Santin,Silvana M. de O.; Silva,Cleuza C. da; Kaplum,VanessaThe chemical study of the orchid Maxillaria picta resulted in the isolation of the bioactive stilbenes phoyunbene B and phoyunbene C, in addition to four phenolic acids, one xanthone, steroidal compounds and two triterpenes. Crude extract, fractions, subfractions and the isolated xanthone were evaluated for anticancer activity against human tumor cell lines and against evolutionary forms of T. cruzi and L. amaz...
Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae
Rosa,Elisa A. da; Silva,Beatriz C. e; Silva,Francielly M. da; Tanaka,Clara M. A.; Peralta,Rosane M.; Oliveira,Cecília M. A. de; Kato,LucíliaA atividade antioxidante, avaliada pelo método DPPH (1,1-difenil-2-picrilidrazila), e o teor em compostos fenólicos totais do extrato bruto metanólico e frações das folhas da espécie Palicourea rigida Kunth, Rubiaceae, foram quantificadas neste trabalho. Apesar da baixa atividade apresentada pelo extrato bruto (500 ppm), a fração acetato de etila apresentou atividade moderada (192 ppm) e o maior teor de fenólic...
Abietatrienes diterpenoids from Sagittaria montevidensis SSP Montevidensis
Tanaka,Clara M. A.; Radke,Vanessa S. C. O.; Silva,Cleuza C. da; Nakamura,Celso V.; Oliveira,Pollyanna L. de; Kato,Lucilia; Oliveira,Cecília M. A. deThe antimicrobial properties of the hexane, hexane/EtOAc and methanol fractions of the fresh petioles of Sagittaria montevidensis ssp montevidensis (Alismataceae) were evaluated against fungi and Gram-negative and Gram-positive bacteria. A new abietatriene-type diterpenoid, 3β,7α-dihydroxi-abieta-8,11,13-triene and the known 3β-hydroxy-abieta-8,11,13-trien-7-one were isolated from the most active fraction teste...
Abietane diterpenes from Sagittaria montevidensis ssp montevidensis Charm. &...
Radke,Vanessa S. C. de O.; Amaral,Maria do Carmo E.; Schuquel,Ivânia T. A.; Silva,Cleuza C. da; Oliveira,Cecília M. A. de; Tanaka,Clara M. A.Two new abietane-type diterpenes, 3beta-hydroxy-9alpha, 13alpha-epidioxyabiet-8(14)-ene (1) and 3-oxo-9alpha,13alpha-epidioxyabiet-8(14)-ene (2), were isolated from the methanolic crude extract of the petioles of Sagittaria montevidensis ssp montevidensis (Alismataceae). The structures of 1 and 2 were determined on the basis of spectrometric analyses including HREIMS, IR as well as ¹H and 13C 1 and 2D NMR.
Synthesis and antiproliferative activity of novel limonene derivatives with a s...
Figueiredo,Isis M.; Santos,Luciane V. dos; Costa,Willian F. da; Carvalho,João E. de; Silva,Cleuza C. da; Sacoman,Juliana L.; Kohn,Luciana K.A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12...
Chemical composition and antifungal activity of the essential oil of Hyptis ova...
Oliveira,Cecília M. A. de; Silva,Maria do Rosário R.; Kato,Lucília; Silva,Cleuza C. da; Ferreira,Heleno D.; Souza,Lúcia K. H.The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the essential oil was isolated by column chromatography and identified by spectroscopic methods as (R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro activity against four dermatophyte fung...
Triterpenic acids from Eugenia moraviana
Lunardi,Inês; Peixoto,Juliana L. B.; Silva,Cleuza C. da; Shuquel,Ivânia T. A.; Basso,Ernani A.; Vidotti,Gentil J.A novel triterpene, characterized as 6alpha-hydroxybetulinic acid, was isolated from the leaves and stems of Eugenia moraviana (Myrtaceae), known in Brazil as Cambuí, together with three known compounds, platanic acid, betulinic acid and beta-sitosterol. Unequivocal ¹H and 13C assignments of 6alpha-hydroxybetulinic acid (3beta,6alpha-dihydroxy-20(29)-lupen-28-oic acid) and platanic acid were undertaken by spect...
Controlling factors determining the selective HSCN addition to double bonds and...
Oliveira,Cecilia M. de; Silva,Cleuza C. da; Collins,Carol H.; Marsaioli,Anita J.The reactivity of terminal and trisubstituted double bonds of monoterpenes with HSCN has been examined by GC giving evidence that kinetics is responsible for the chemoselective addition to terminal double bonds in terpenes. The results show that the addition to the terminal double bond is about 17 times faster than for trisubstituted double bonds and that the presence of the first SCN group in the molecule prev...