24 documents found, page 1 of 3
Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican...
Silva,Denise Rossato; Freitas,Alana Ambos; Guimarães,Amanda Reis; D’Ambrosio,Lia; Centis,Rosella; Muñoz-Torrico,Marcela; Visca,DinaABSTRACT Objective: To evaluate lung function in a cohort of patients with a history of pulmonary tuberculosis in Brazil, as well as to evaluate the decline in lung function over time and compare it with that observed in similar cohorts in Mexico and Italy. Methods: The three cohorts were compared in terms of age, smoking status, pulmonary function test results, six-minute walk test results, and arterial blood ...
Smoking prevalence and effects on treatment outcomes in patients with tuberculosis
de Vargas,Kellyn Rocha; Freitas,Alana Ambos; Azeredo,Ana Cláudia Vasconcellos; Silva,Denise RossatoSUMMARY OBJECTIVE: More than 20% of tuberculosis (TB) cases worldwide are attributable to smoking, and it is associated with an increased risk of latent and active TB, recurrence, and mortality. The aim of this study is to assess the smoking prevalence and the effects on treatment outcomes in TB patients. METHODS: A prospective cohort study was conducted in patients with a recent TB diagnosis. The smoking statu...
Diagnosis of tuberculosis: a consensus statement from the Brazilian Thoracic As...
Silva,Denise Rossato; Rabahi,Marcelo Fouad; Sant’Anna,Clemax Couto; Silva-Junior,José Laerte Rodrigues da; Capone,Domenico; Bombarda,SidneyABSTRACT Early, accurate diagnosis of tuberculosis is one of the major pillars of the control of the disease. The purpose of this consensus statement is to provide health professionals with the most current, useful evidence for the diagnosis of tuberculosis in Brazil. To that end, the Tuberculosis Committee of the Brazilian Thoracic Association brought together 14 members of the Association with recognized expe...
Tuberculosis and COVID-19, the new cursed duet: what differs between Brazil and...
Silva,Denise Rossato; Mello,Fernanda Carvalho de Queiroz; D’Ambrosio,Lia; Centis,Rosella; Dalcolmo,Margareth Pretti; Migliori,Giovanni BattistaABSTRACT On April 1st, 2020, COVID-19 surpassed tuberculosis regarding the number of deaths per day worldwide. The combination of tuberculosis and COVID-19 has great potential for morbidity and mortality. In addition, the COVID-19 pandemic has had a significant impact on the diagnosis and treatment of tuberculosis. In this review article, we address concurrent tuberculosis and COVID-19, with particular regard t...
Association between the radiological presentation and elapsed time for the diag...
Muller,Guilherme Seara; Faccin,Carlo Sasso; Silva,Denise Rossato; Dalcin,Paulo de Tarso RothABSTRACT Objective: To evaluate the radiological presentation of patients with pulmonary tuberculosis diagnosed in the emergency department and to investigate its association with the time to diagnosis. Methods: This was a prospective observational study involving patients diagnosed with pulmonary tuberculosis in the emergency department of a tertiary university hospital in southern Brazil. Chest X-rays taken o...
Shortened tuberculosis treatment regimens: what is new?
Silva,Denise Rossato; Mello,Fernanda Carvalho de Queiroz; Migliori,Giovanni BattistaABSTRACT Given the global burden of tuberculosis, shortened treatment regimens with existing or repurposed drugs are needed to contribute to tuberculosis control. The long duration of treatment of drug-susceptible tuberculosis (DS-TB) is associated with nonadherence and loss to follow up, and the treatment success rate of multidrug-resistant tuberculosis (MDR-TB) is low (approximately 50%) with longer regimens....
Managing severe tuberculosis and its sequelae: from intensive care to surgery a...
Tiberi,Simon; Torrico,Marcela Muñoz; Rahman,Ananna; Krutikov,Maria; Visca,Dina; Silva,Denise Rossato; Kunst,Heinke; Migliori,Giovanni BattistaABSTRACT Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continue to challenge physicians and public health specialists. Global treatment outcomes continue to be unsatisfactory, positive outcomes being achieved in only 54% of patients. Overall outcomes are even worse in patients infected with highly resistant strains. Treating MDR-/XDR-TB is difficult because of fr...
International collaboration among medical societies is an effective way to boos...
Migliori,Giovanni Battista; Centis,Rosella; D’Ambrosio,Lia; Silva,Denise Rossato; Rendon,AdrianABSTRACT Objective: Most studies of tuberculosis originate from high-income countries with a low incidence of tuberculosis. A review of the scientific production on tuberculosis in Latin American countries, most of which are low- or middle-income countries (some with high or intermediate tuberculosis incidence rates), would improve the understanding of public health challenges, clinical needs, and research prio...
Latent tuberculosis infection in patients with rheumatic diseases
Anton,Camila; Machado,Felipe Dominguez; Ramirez,Jorge Mario Ahumada; Bernardi,Rafaela Manzoni; Palominos,Penélope Esther; Brenol,Claiton ViegasABSTRACT Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leadin...
Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of o...
Silva,Denise Rossato; Muñoz-Torrico,Marcela; Duarte,Raquel; Galvão,Tatiana; Bonini,Eduardo Henrique; Arbex,Flávio Ferlin; Arbex,Marcos AbdoABSTRACT Tuberculosis continues to be a major public health problem. Although efforts to control the epidemic have reduced mortality and incidence, there are several predisposing factors that should be modified in order to reduce the burden of the disease. This review article will address some of the risk factors associated with tuberculosis infection and active tuberculosis, including diabetes, smoking, alcoho...