9 documents found, page 1 of 1
Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colleto...
Chapla,Vanessa M.; Zeraik,Maria L.; Cafeu,Mariana C.; Silva,Geraldo H.; Cavalheiro,Alberto J.; Bolzani,Vanderlan S.; Young,Maria C. M.One new natural product, 1-phenylethyl-O-a-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia s...
Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versic...
Gubiani,Juliana R.; Teles,Helder L.; Silva,Geraldo H.; Young,Maria Cláudia M.; Pereira,José O.; Bolzani,Vanderlan S.; Araujo,Angela R.Six known compounds, three peptide derivatives: cyclo-(tryptophyl-phenylalanyl) (2), diketopiperazine dimer WIN 64821 (3) and 3-hydroxy-15H-tryptophenaline (4), one adenine derivative: 2-hydroxy-6-N-isopentenyl-adenine (5), one phtalide derivative: 4-methoxyphtalide (1) and one benzoic acid derivative: 3-hydroxy-4-(1-hydroxy-1,5-dimethyl-hexyl) benzoic acid (6), were isolated from the ethyl acetate extract of t...
ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS U...
Gubiani,Juliana R.; Habeck,Thomas R.; Chapla,Vanessa M.; Silva,Geraldo H.; Bolzani,Vanderlan S.; Araujo,Angela R.Seven phenolic derivatives including p-hydroxyphenyllactic acid (1), p-hydroxybenzoic acid (2), p-hydroxybenzaldehyde (3), phenyllactic acid (4), n-butyl-3,4-dihydroxybenzoate (5), n-hexyl-3,4-dihydroxybenzoate (6) and n-octyl-3,4-dihydroxybenzoate (7) were produced using Camarops sp. via the one strain-many compounds (OSMAC) approach. Their structures were determined using 2D NMR and ESI-MS spectra and were co...
Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade...
Zanardi,Lisinéia M.; Bolzani,Vanderlan da S.; Cavalheiro,Alberto J.; Silva,Dulce H. Siqueira; Trevisan,Henrique C.; Araujo,Angela R.; Silva,Geraldo H.SESQUITERPENES PRODUCED BY ENDOPHYTIC FUNGUS Phomopsis cassiae WITH ANTIFUNGAL AND ACETYLCHOLINESTERASE INHIBITION ACTIVITIES. Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, includin...
Development and validation of a HPLC method for standardization of herbal and c...
Batista,Andrea N. de L.; Colombo,Renata; Pascoli,Inara C. de; Teles,Helder L.; Silva,Geraldo H.; Bomfim,Giovanni C. C.; Burgos,Rosilene C. R.Myrcia uniflora Barb. Rodr., Myrtaceae, popularly known as "pedra-hume-caá" in Brazil, is sold as dry extracts in capsules or as tinctures for the treatment of diabetes mellitus. Previous phytochemical studies on this species described the occurrence of the flavonoids mearnsitrin and myricitrin. In the present study, the chromatographic profiles of M. uniflora leaves and commercial extracts were determined usin...
Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum ...
Silva,Geraldo H.; Oliveira,Camila M. de; Teles,Helder L.; Bolzani,Vanderlan da S.; Araujo,Angela R.; Pfenning,Ludwig H.; Young,Maria Claudia M.A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines ...
Identification of the antimicrobial substances produced by Solanum palinacanthu...
Pereira,Aline C.; Oliveira,Denilson F.; Silva,Geraldo H.; Figueiredo,Henrique C.P.; Cavalheiro,Albero J.; Carvalho,Douglas A.; Souza,Luciana P.To find out natural antimicrobial agents as alternative in therapeutics and to preserve food, the methanol extract of Solanum palinacanthum aerial parts was submitted to purification steps guided by antibacterial and antifungal assays. As a consequence, the flavonoid rutin and 3,5-dicaffeoylquinic acid were isolated by column chromatographyand high performance liquid chromatography, and identified by mass and n...
Purification of an antibacterial compound from Lantana lilacina
Pereira,Aline C.; Carvalho,Hudson W. P.; Silva,Geraldo H.; Oliveira,Denilson F.; Figueiredo,Henrique C. P.; Cavalheiro,Alberto J.; Carvalho,Douglas A.Since the methanol extract of Lantana lilacina leaves collected in the city of Lavras (MG, Brazil) showed antibacterial properties in a preliminary study, a fractionation process guided by agar diffusion assays with Aeromonas hydrophila, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus was carried out to purify and identify the active compounds. After solvent partition and several chromatogra...
Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicou...
Cafêu,Mariana C.; Silva,Geraldo H.; Teles,Helder L.; Bolzani,Vanderlan da S.; Araújo,Ângela R.; Young,Maria Cláudia M.; Pfenning,Ludwig H.Five compounds, 2-hexyl-3-methyl-butanodioic acid (1), cytochalasin D (2), 7-dechlorogriseofulvin (3), cytochalasin B (4) and griseofulvin (5), have been isolated from the endophytic fungus Xylaria sp., and their structures were elucidated on the basis of spectroscopic data. In the bioautography assay against Cladosporium cladosporioides and Cladosporium sphaerospermum, compounds 1 and 2 were found to be active...