31 documents found, page 1 of 4
Characterization of oxidative stress in animal model of neonatal hypoxia
Bochenek,Liliane de Mello Santos; Parisotto,Eduardo Benedetti; Salomão,Evelyn de Andrade; Maldonado,Maria José Martins; Silva,Iandara SchettertABSTRACT Purpose To evaluate the oxidative stress in swine neonates submitted to hypoxia. Methods Ten large white piglets, healthy newborns, of both sexes, were divided into two groups and submitted to an experimental hypoxia protocol with reduced inspired oxygen fraction. The hypoxia group, composed of six animals, was submitted to oxygen reduction for 180 min. The animals in the control group, n = 4, were han...
Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAM...
Santos Neto,Abilio Torres dos; Silva,Iandara Schettert; Ivo,Maria Lucia; Rodrigues,Camila Tozaki; Parisotto,Eduardo Benedetti; Ramalho,Rondon TostaAbstract Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea. Methods: Eighteen male albino Wistar rats were divided into three groups. NG-nitro-L-arginine methyl ester (L-NAME) was intraperitoneally administered to induce oxidative stress. T...
Muscle changes with high-intensity aerobic training in an animal model of renal...
Togoe,Eliane Barbosa; Silva,Iandara Schettert; Cury,Juliana Loprete; Guarnier,Flavia AlessandraAbstract Purpose: To analyze the muscle changes with high-intensity aerobic training (HIAT) in an animal model of renal disease (RD). Methods: Twenty one adult Wistar rats were divided into 3 groups: healthy sedentary (HS), RD sedentary (RDS), RD aerobic training (RDAT). RDS and RDAT were subjected to unilateral renal ischemia-reperfusion (10 min) and 21days after that, RDAT was subjected to 6 weeks HIAT (swimm...
Use of cyanoacrylate-based surgical adhesives associated to the macroporous tap...
Ilgenfritz Neto,João; Aydos,Ricardo Dutra; Silva,Iandara Schettert; Takita,Luiz Carlos; Abreu,Antônio Carlos de; Silva,Cynthia Alexia CunhaAbstract Purpose: To compare the use of new cyanoacrylate surgical adhesive associated with macroporous tapes in cutaneous synthesis. Methods: Male Wistar rats with a longitudinal incision of 4cm were used on the back, divided into four groups: GI used octyl-cyanoacrylate (Dermabond®), GII used N-2-butylcyanoacrylate, GIII used octyl-cyanoacrylate and macroporous tape and GIV used N-2-butyl cyanoacrylate and ma...
Oxidative stress effects in the uterus, placenta and fetus of pregnant rats sub...
Silveira,Adriano Silva; Aydos,Ricardo Dutra; Ramalho,Rondon Tosta; Silva,Iandara Schettert; Caldas,Ruy de Araujo; Santos Neto,Abílio Torres dosAbstract Purpose: To evaluate the effects of oxidative stress in pregnant rats submitted to acute and chronic stress, relating to alterations in the uterus, placenta and fetus. Methods: Twenty-four female Wistar albino (Rattus norvegicus), were divided into four groups, for induction of oxidative stress the animals were submitted to cold and physical immobilization. Plasma fasting glucose and MDA were determine...
Potencial of different hydroxyapatites as biomaterials in the bone remodeling
Cassino,Pedro Carvalho; Rosseti,Larissa Schimidt; Ayala,Osmar Ignácio; Martines,Marco Antônio Utrera; Portugual,Luciane CandeloroAbstract Purpose: To analyze the therapeutic potentials of different hydroxyapatites used for the correction of bone defects in rats. Methods: Forty rats, male, albino wistar, were distributed in 4 groups. They were submitted to a 3.5 mm defect in tibia. They received low purity hydroxyapatite, Strontium hydroxyapatite and hydroxyapatite doped with gallium, having a seven day evaluation time. Histopathology sli...
The aplication of cyanoacrilate surgical glue on skin suture in rats
Ilgenfritz Neto,João; Aydos,Ricardo Dutra; Silva,Iandara Schettert; Ramalho,Rondon Tosta; Ilgenfritz Júnior,João; Campos,Gerson Gattats Orro deAbstract Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each ...
Pulmonary oxidative stress in diabetic rats exposed to hyperoxia
Paiva,Letícia Alves; Silva,Iandara Schettert; Souza,Albert Schiaveto de; Cassino,Pedro CarvalhoAbstract Purpose: To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes. Methods: Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed: 21%, 50%, 75% and 100% (hyperoxia). In each group five animals were randomly induced to diabetes by means of at a dose of 55 mg/kg of stre...
Animal models of obesity in rodents. An integrative review
Fernandes,Melina Ribeiro; Lima,Nayara Vieira de; Rezende,Karoline Silva; Santos,Isabela Caroline Marques; Silva,Iandara SchettertABSTRACT PURPOSE: To perform an integrative review of the main animal disease models in rodents used for obesity. METHODS: Research was conducted in the CAPES Portal database using the following keywords "obesity animal models, diet and rodents", published between the years 2010 to 2016. We found 108 articles, of which 19 were selected and analyzed in full for this study. RESULTS: Larger part of publications oc...
Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small...
Brasileiro,José Lacerda; Ramalho,Rondon Tosta; Aydos,Ricardo Dutra; Silva,Iandara Schettert; Takita,Luis Carlos; Marks,Guido; Assis,Peterson Vieira dePURPOSE: To investigate the action of pentoxifylline (PTX) and prostaglandin E1 (PGE1) on ischemia and reperfusion of small intestine tissue in rats, using immunohistochemical analysis. METHODS: Thirty-five Wistar rats were distributed as follows: group A (n=10): subjected to intestinal ischemia and reperfusion for 60 min, with no drugs; group B (n=10): PTX given during tissue ischemia and reperfusion; group C ...