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In major affective disorders, early life trauma predict increased nitro-oxidati...
Moraes, Juliana Brum; Maes, Michael; Roomruangwong, Chutima; Bonifacio, Kamila Landucci; Barbosa, Decio Sabbatini; Vargas, Heber OdebrechtEarly life trauma (ELT) may increase the risk towards bipolar diso rder (BD) and major depression (MDD), disorders associated with activated neuro-oxidative and neuro-nitrosative stress (O&NS) p athways. It has remained elusive whether ELTs are associated with O&NS and which ELTs are associated with disti nct affective disorder phenotypes. This case-control study examined patients with BD ( n = 68) and MDD ( n ...
Major differences in neurooxidative and neuronitrosative stress pathways betwee...
Maes, Michael; Bonifacio, Kamila Landucci; Morelli, Nayara Rampazzo; Vargas, Heber Odebrecht; Barbosa, Décio Sabbatini; Carvalho, André F.Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder (MDD). However, only a handful of studies have directly compared alterations in O&NS pathways among patients with MDD and BD types I (BPI) and BPII. Thus, the current study compared superoxide dismutase (SOD1), lipid hydroperoxides (L...
Generalized anxiety disorder (GAD) and comorbid major depression with GAD are c...
Maes, Michael M; Bonifacio, Kamila Landucci; Morelli, Nayara Rampazzo; Vargas, Heber Odebrecht V; Moreira, Estefânia GastaldelloAccumulating evidence shows that nitro-oxidative pathways play an important role in the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD) and maybe anxiety disorders. The current study aims to examine superoxide dismutase (SOD1), catalase, lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), malondialdehyde (MDA), glutathione (GSH), ...