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Analgesic and side effects of intravenous recombinant Phα1β
Rigo,Flavia Karine; Rossato,Mateus Fortes; Borges,Vanessa; Silva,Juliana Figueira da; Pereira,Elizete Maria Rita; Ávila,Ricardo Andrez Machado deABSTRACT Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the those of the native toxin. However, from a clinical perspective, the intrathecal administration limits the use of anesthetic drugs in patients. Therefore, this s...
Biomarkers in Alzheimer disease
Torres,Karen Cecília de Lima; Santos,Rodrigo Ribeiro dos; Mapa,Filipe Camilo; Moraes,Flávia Lanna de; Moraes,Edgar Nunes de; Silva,Marco Aurélio Romano<p><b>OBJECTIVE:</b> To present the ongoing researches for biomarkers in Alzheimer disease<br> <b>METHODS:</b> Bibliographic review, starting from 2000, utilizing PubMed data bank.<br> <b>RESULTS:</b> This revision presents the actual evidences of the main markers involved in Alzheimer disease including the molecular (presented in blood and cerebrospinal fluid), the associated with image (pósitron emissi...