3 documents found, page 1 of 1
Rastreamento para Hipercolesterolemia Familiar em Pequenos Municípios: A Experi...
Jannes,Cinthia Elim; Silvino,Júnea Paolucci Paiva; Silva,Pãmela Rodrigues de Souza; Lima,Isabella Ramos; Tada,Mauricio TeruoResumo Fundamento A hipercolesterolemia familiar (HF) é uma doença genética dominante que se caracteriza por níveis sanguíneos elevados de colesterol de lipoproteína de baixa densidade (LDL-C), e está associada à ocorrência de doença cardiovascular precoce. No Brasil, o HipercolBrasil, que é atualmente o maior programa de rastreamento em cascata para HF, já identificou mais de 2.000 indivíduos com variantes gen...
Predictors of Family Enrollment in a Genetic Cascade Screening Program for Fami...
Silva,Pãmela Rodrigues de Souza; Jannes,Cinthia Elim; Oliveira,Theo G. M.; Gómez,Luz Marina Gómez; Krieger,José E.; Santos,Raul D.Abstract Background: Genetic cascade screening is the most cost-effective method for the identification of individuals with familial hypercholesterolemia (FH), but the best strategies for the enrollment of at-risk individuals in a FH screening program are not fully known. Objective: The aim of this study is to identify the best predictors of familial enrollment into genetic screening, using features derived fro...
High risk of respiratory diseases in children in the fire period in Western Amazon
Silva,Pãmela Rodrigues de Souza; Ignotti,Eliane; Oliveira,Beatriz Fátima Alves de; Junger,Washington Leite; Morais,Fernando; Artaxo,Paulo; Hacon,SandraABSTRACT OBJECTIVE To analyze the toxicological risk of exposure to ozone (O3) and fine particulate matter (PM2.5) among schoolchildren.. METHODS Toxicological risk assessment was used to evaluate the risk of exposure to O3 and PM2.5 from biomass burning among schoolchildren aged six to 14 years, residents of Rio Branco, Acre, Southern Amazon, Brazil. We used Monte Carlo simulation to estimate the potential int...