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BRD9 status is a major contributor for cysteine metabolic remodeling through MS...

Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, Duarte

Publisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...


H2S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management to...

Hipólito, Ana; Mendes, Cindy; Martins, Filipa; Lemos, Isabel; Francisco, Inês; Cunha, Fernando; Almodôvar, Teresa; Albuquerque, Cristina

Funding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020), and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). The study was partially supported by a Merck KGaA, Darmstad...


Interaction between NSCLC Cells, CD8+ T-Cells and Immune Checkpoint Inhibitors ...

Freitas-Dias, Catarina; Gonçalves, Filipe; Martins, Filipa; Lemos, Isabel; Gonçalves, Luís G.; Serpa, Jacinta

Funding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). Filipa Martins was funded by an FCT individual Ph.D. fell...


Metabolic profiling and combined therapeutic strategies unveil the cytotoxic po...

Mendes, Cindy; Lemos, Isabel; Hipólito, Ana; Abreu, Bruna; Freitas-Dias, Catarina; Martins, Filipa; Pires, Rita F.; Barros, Hélio; Bonifácio, Vasco D.B.

Funding Information: The institutions are funded by Fundac\u00B8 \u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health [grant numbers UIDB/04462/2020 and UIDP/04462/2020], to MOSTMICRO-ITQB [grant numbers UIDB/04612/2020 and UIDP/04612/2020] and the Associated Laboratory LS4FUTURE [grant number LA/P/...


NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF ...

Mendes, Cindy; Lemos, Isabel; Francisco, Inês; Almodôvar, Teresa; Cunha, Fernando; Albuquerque, Cristina; Gonçalves, Luís G.; Serpa, Jacinta

Funding Information: The institutions are funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). Cindy Mendes was funded by a FCT individual Ph.D. fellowshi...


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