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Mexican calea (Calea zacatechichi Schltdl.) interferes with cholinergic and dop...

Garcia, Maria Rita; Gil-Izquierdo, Ángel; Ferreres, Federico; Andrade, Paula B.; Mineiro, Tiago; Seabra, Vítor; Videira, Romeu A.; Silva, Diana Dias da

The use of “Mexican calea” (Calea zacatechichi Schltdl.) in ritualistic ceremonies, due to its dream-inducing effects, was until recently limited to indigenous communities in Mexico. However, the plant has recently gained popularity in Western societies being commonly used in recreational settings. Despite the traditional and recreational uses, mechanisms underlying its reported oneirogenic effects remain unkno...


Chemical characterization and in vitro studies on the impact of the 'Dream Herb...

Garcia, Maria Rita; Mineiro, Tiago; Andrade, Paula B.; Ferreres, Federico; Gil-Izquierdo, Ángel; Seabra, Vítor; Dias-da-Silva, Diana

Background: An increasing number of psychoactive plants, particularly those with long history of use on ritualistic practices, are now being progressively used in recreational context, many of which remaining unregulated [1]. Calea zacatechichi is traditionally used in divination rituals, due to its oneirogenic properties. Yet, considering the psychoactive effects of this ‘Dream Herb’ and easiness of purchase, ...

Date: 2024   |   Origin: Scientific Letters

Preliminary chemical profile and in vitro pharmacological evaluation of the hal...

Garcia, Maria Rita; Dutka, Mykhaylo; Guimarães, Sofia; Andrade, Paula B.; Seabra, Vítor; Dias-da-Silva, Diana

Background: For the last few years, Ayahuasca ceremonies have been gaining popularity in recreational settings in Europe and North America [1]. Similar to Psychotria viridis, Diplopterys cabrerana is also suggested to contain the psychoactive compound N,N-dimethyltryptamine, and is therefore used in Ayahuasca rituals for its ability to induce hallucinations, euphoria and entheogenic effects [1-3]. However, whil...

Date: 2024   |   Origin: Scientific Letters

Chemical characterization and in vitro studies on the impact of the 'Dream Herb...

Garcia, Maria Rita; Mineiro, Tiago; Andrade, Paula B.; Ferreres, Federico; Gil-Izquierdo, Ángel; Seabra, Vítor; Silva, Diana; Gomes, Nelson G. M.

An increasing number of psychoactive plants, particularly those with long history of use on ritualistic practices, are now being progressively used in recreational context, many of which remaining unregulated. Calea zacatechichiis traditionally used in divination rituals, due to its oneirogenic properties. Yet, considering the psychoactive effects of this ‘Dream Herb’and easiness of purchase, the potential for ...


Preliminary chemical profile and in vitro pharmacological evaluation of the hal...

Garcia, Maria Rita; Dutka, Mykhaylo; Guimarães, Sofia; Andrade, Paula B.; Seabra, Vítor; Diana Dias da Silva; Gomes, Nelson G. M.

For the last few years, Ayahuasca ceremonies have been gaining popularity in recreational settings in Europe and North America [1]. Similar to Psychotria viridis, Diplopterys cabreranais also suggested to contain the psychoactive compound N,N-dimethyltryptamine, and is therefore used in Aya-huasca rituals for its ability to induce hallucinations, euphoria and entheogenic effects [1-3]. However, while informatio...


Development of a platform to align education and practice: bridging academia an...

Costa, Filipa Alves da; Martins, Ana Paula; Veiga, Francisco; Ramalhinho, Isabel; Lobo, José Manuel Sousa; Rodrigues, Luís; Granadeiro, Luiza

Limited fitness for practice may result from a mismatch between education and practice. Aiming to meet the common interests of academics and practitioners, the Portuguese Pharmaceutical Society (PPS) developed the Education and Practice Platform (EPP). The EPP includes one representative from each pharmacy faculty, and all Councils of Speciality Boards of Practice. Brainstorming with involved parties enabled sh...


Development of a platform to align education and practice: bridging Academia an...

Alves da Costa, Filipa; Martins, Ana Paula; Veiga, Francisco; Ramalhinho, Isabel; Sousa Lobo, José Manuel; Rodrigues, Luís; Granadeiro, Luiza

Limited fitness for practice may result from a mismatch between education and practice. Aiming to meet the common interests of academics and practitioners, the Portuguese Pharmaceutical Society (PPS) developed the Education and Practice Platform (EPP). The EPP includes one representative from each pharmacy faculty, and all Councils of Speciality Boards of Practice. Brainstorming with involved parties enabled sh...


Development of a platform to align education and practice: bridging academia an...

Alves da Costa, Filipa; Martins, Ana Paula; Veiga, Francisco; Ramalhinho, Isabel; Sousa Lobo, José Manuel; Rodrigues, Luís; Granadeiro, Luiza

Limited fitness for practice may result from a mismatch between education and practice. Aiming to meet the common interests of academics and practitioners, the Portuguese Pharmaceutical Society (PPS) developed the Education and Practice Platform (EPP). The EPP includes one representative from each pharmacy faculty, and all Councils of Speciality Boards of Practice. Brainstorming with involved parties enabled sh...


Metabolism is required for the expression of ecstasy-induced cardiotoxicity in ...

Carvalho, Márcia; Remião, Fernando; Milhazes, Nuno; Borges, Fernanda; Fernandes, Eduarda; Monteiro, Maria do Céu; Gonçalves, Maria José; Seabra, Vítor

Cardiovascular complications associated with 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) abuse have increasingly been reported. The indirect effect of MDMA mediated by a sustained high level of circulating biogenic amines may contribute to the cardiotoxic effects, but other factors, like the direct toxic effects of MDMA and its metabolites in cardiac cells, remain to be investigated. Thus, the objective o...


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