4 documents found, page 1 of 1
Alzheimer’s disease: the neuroprotective potential of novel synthetic compounds...
Monteiro , A. R.; Maia , M.; Sousa , E.; Remião , F.; Silva , R.Background: Alzheimer’s disease (AD) is a progressive neurological disorder characterized by cognitive decline associated, specifically, with the degeneration of cholinergic neurons [1]. Although the etiology of the disease remains elusive, with several pathophysiological mechanisms contributing to disease progression, two main pathological hallmarks are well described, namely the presence of 1) neurofibrillary...
Neuroprotective effects of mitochondria-targeted antioxidants in a Parkinson’s ...
Costa , I.; Benfeito , S.; Silva , V.; Cagide , F.; Borges , F.; Remião , F.; Silva , R.Background: Parkinson’s disease (PD) is a neurodegenerative disease with early prominent death of dopaminergic neurons in the substantia nigra pars compacta, concurrently with Lewys body formation, iron accumulation, oxidative stress and ferroptosis[1–3]. Since there is no effective therapy capable of stopping/delaying disease progression, phenolic acids such as hydroxycinnamic and hydroxybenzoic acids (HCA and...
3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents fo...
Silva , V.; Benfeito, S.; Lima , C.; Chavarria, D.; Gonçalves, T.; Costa , I.; Remião , F.; Borges, F.; Silva , R.Background: Parkinson’s Disease (PD) is a multifactorial, complex and progressive neurodegenerative disease, characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta [1,2]. Several pathophysiological mechanisms are involved in PD, namely Lewy bodies formation, mitochondrial dysfunction, neuroinflammation, oxidative stress and iron accumulation within the brain [3]. Iron tr...
New 8-hydroxyquinoline derivatives as promising therapeutic approaches targetin...
Marques-Oliveira , R.; Alfenim, A. R.; Soares , P.; Borges , F.; Remião, F.; Fernandes, C.; Silva , R.Background: Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis are recognized as the most prevalent neurodegenerative diseases (NDs), presenting a huge burden for society. These diseases share common pathophysiological mechanisms, such oxidative stress, dysfunction in iron metabolism, ferroptosis, and protein misfolding [1-4]. Given their powerful metal chelating and antioxidant propert...