3 documents found, page 1 of 1
Dual-action breakthrough: Fiscalin derivatives targeting amyloid burden and ace...
Costa , Inês; Barbosa , Daniel José; Sousa , Maria Emília; Silva , RenataBackground: Alzheimer’s disease (AD) is the most common age-related dementia, characterized by neurodegeneration associated with the accumulation of amyloid-beta (Aβ) peptides and hyperphosphorylated Tau, mitochondrial dysfunction, and oxidative stress, among other pathological features [1]. Moreover, reduced acetylcholine levels contribute to the cognitive impairment and memory deficits characteristic of the d...
Unveiling the neuroprotective potential of new xanthene derivatives in Parkinso...
Azevedo , Rita; Costa , Inês; Maia , Miguel; Martins , Márcia; Remião , Fernando; Sousa, Maria Emília; Silva , RenataBackground: Parkinson's disease (PD) is a neurodegenerative condition marked by the premature loss of dopaminergic neurons in the substantia nigra pars compacta. Additionally, PD is linked to several neuropathological processes, such as the formation of Lewy bodies, neuroinflammation, mitochondrial dysfunction, ferroptosis and oxidative stress [1-4]. Despite the notable progress in PD research, the development ...
Neurotoxicity Evaluation of Four Structurally Similar Synthetic Cathinones in a...
Fonseca , Catarina da; Malheiro, Rui; Remião, Fernando; Pedro Silva, João; Silva , RenataBackground: Synthetic cathinones are potent central nervous system (CNS) stimulants that induce diverse neurological and psychiatric effects such as delusions, hallucinations, and agitation [1]. This fast-expanding class of new psychoactive substances (NPS) represented the majority of those seized in the European Union in 2021 [2]. Despite the growing recreational use, knowledge on their neurotoxic mechanisms, ...