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Synthesis of selenium-quinone hybrid compounds with potential antitumor activit...
Jardim, Guilherme A. M.; Cruz, Eduardo H. G. da; Valença, Wagner O.; Lima, Daisy J. B.; Cavalcanti, Bruno C.; Pessoa, Claudia; Rafique, JamalAbstract: In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), ...
On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor act...
Silva Júnior, Eufrânio N. da
Antifungal activity of naphthoquinoidal compounds In vitro against fluconazole-...
Andrade Neto, João Batista de; Silva, Cecília R. da; Campos, Rosana S.; Siebra, Janaína T.; Silva, Rose A. C.; Gaspar, Danielle M.In recent decades, the incidence of candidemia in tertiary hospitals worldwide has substantially increased. These infections are a major cause of morbidity and mortality; in addition, they prolong hospital stays and raise the costs associated with treatment. Studies have reported a significant increase in infections by non-albicans Candida species, especially C. tropicalis. The number of antifungal drugs on the...
Potent antileukemic action of naphthoquinoidal compounds : evidence for an intr...
Cavalcanti, Bruno C.; Cabral, Igor O.; Rodrigues, Felipe A. R.; Barros, Francisco W. A.; Rocha, Danilo D.; Magalhães, Hemerson I. F.; Moura, Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β- lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor ce...
Synthesis of quinoidal molecules: strategies towards bioactive compounds with a...
Silva Júnior, Eufrânio N. da