3 documents found, page 1 of 1
Dengue virus capsid protein facilitates genome compaction and packaging
Boon, Priscilla L. S.; Silva Martins, Ana; Lim, Xin Ni; Enguita, Francisco J.; Santos, Nuno C.; Bond, Peter J.; Wan, Yue; Martins, Ivo C.Dengue virus (DENV) is a single-stranded (+)-sense RNA virus that infects humans and mosquitoes, posing a significant health risk in tropical and subtropical regions. Mature virions are composed of an icosahedral shell of envelope (E) and membrane (M) proteins circumscribing a lipid bilayer, which in turn contains a complex of the approximately 11 kb genomic RNA with capsid (C) proteins. Whereas the structure o...
Hoarseness as the presentation of immunoglobulin G4-related disease with vocal ...
Dourado, Eduardo; Silva Martins, Ana; Fonseca, João EuricoImmunoglobulin G4-related disease is a rare fibroinflammatory infiltrative condition with heterogeneous clinical manifestations. We present the case of a 64-year-old man that presented with hoarseness due to vocal cord involvement, a particularly rare manifestation. A large mediastinal mass compressing thoracic large vessels was also identified. The patient was initially treated with glucocorticoids but had rel...
Structural and functional properties of the capsid protein of Dengue and relate...
Faustino, André F.; Silva Martins, Ana; Karguth, Nina; Artilheiro, Vanessa; Enguita, Francisco J.; Ricardo, Joana; Santos, Nuno C.; Martins, Ivo C.Dengue, West Nile and Zika, closely related viruses of the Flaviviridae family, are an increasing global threat, due to the expansion of their mosquito vectors. They present a very similar viral particle with an outer lipid bilayer containing two viral proteins and, within it, the nucleocapsid core. This core is composed by the viral RNA complexed with multiple copies of the capsid protein, a crucial structural...