5 documents found, page 1 of 1
Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ...
Farias,V.X.; Uchoa,P.N.; Aquino,C.P.; Britto,L.R.G.; Fonteles,M.C.; Leal-Cardoso,J.H.; Silva-Alves,K.S.; Havt,A.; Prata,M.M.G.; Heimark,D.B.The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8, and 12 weeks; 65 mg/kg; ip) diabetic rats (DB) and age-matched euglycemic (E) rats were used for the analysi...
Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice
Coelho-de-Souza,A.N.; dos-Santos,C.F.; Lopes-Filho,L.N.; Holanda,F.R.; Oliveira,A.C.; Gomes-Vasconcelos,Y.A.; Oliveira,K.A.; Ferreira-da-Silva,F.W.Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently pharmacologically active, the present study aimed to evaluate the antinociceptive effect of EO from Pterodon poly...
Effects of Lippia sidoides essential oil, thymol, p-cymene, myrcene and caryoph...
Barbosa,R.; Cruz-Mendes,Y.; Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Ribeiro,N.M.; Morais,L.P.; Leal-Cardoso,J.H.Lippia sidoides Cham is a typical herb species of Northeast Brazil with widespread use in folk medicine. The major constituents of the essential oil of L. sidoides (EOLs) are thymol, p-cymene, myrcene, and caryophyllene. Several studies have shown that the EOLs and its constituents have pharmacological effects, including antibacterial, anti-inflammatory, antioxidant and neuroprotective activity. Therefore, this...
Essential oil of Lippia alba and its main constituent citral block the excitabi...
Sousa,D.G.; Sousa,S.D.G.; Silva,R.E.R.; Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Kerntopf,M.R.; Menezes,I.R.A.; Leal-Cardoso,J.H.; Barbosa,R.Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present study evaluated the effects of the essential oil of L. ...
Estragole blocks neuronal excitability by direct inhibition of Na+ channels
Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Peixoto-Neves,D.; Viana-Cardoso,K.V.; Moreira-Júnior,L.; Oquendo,M.B.; Oliveira-Abreu,K.; Albuquerque,A.A.C.Estragole is a volatile terpenoid, which occurs naturally as a constituent of the essential oils of many plants. It has several pharmacological and biological activities. The objective of the present study was to investigate the mechanism of action of estragole on neuronal excitability. Intact and dissociated dorsal root ganglion neurons of rats were used to record action potential and Na+ currents with intrace...