2 documents found, page 1 of 1
Inhibitory activity of psilocybin/psilocin towards the enzymes of the cytochrom...
Brito-da-Costa, A. M.; Silva-Carvalho, M.; Dinis-Oliveira, R. J.; Madureira-Carvalho, Á.; Dias da Silva, D.Background: Psilocybin is a hallucinogen produced by several “magic mushrooms” [1,2]. This prodrug is rapidly metabolized in the organism by alkaline phosphatases and esterases into psilocin, the active drug [1,2]. A scientific gap exists regarding the possible interactions between psilocybin/psilocin and CYP450 enzymes. Since the binding of drugs to CYP450 enzymes can interfere with the metabolism of other sub...
Assessment of the CYP450 inhibitory potential of LSD, 5-MeO-DMT and mescaline: ...
Silva-Carvalho, M.; Brito-da-Costa, A. M.; Dinis-Oliveira, R. J.; Madureira-Carvalho, Á.; Dias da Silva, D.Background: LSD, 5-MeO-DMT and mescaline are classic hallucinogens known for their recreational use, whose consumption increased in the last decades. Despite some available data on the toxicokinetics of these drugs, little is known about their CYP450 metabolism [1,2,3]. Nevertheless, this information is of crucial relevance to predict drug-drug interactions and understand toxicological phenomena, in particular ...