8 documents found, page 1 of 1
Polysaccharide-mediated stabilization of bacterial nanocellulose dispersions: E...
Silva-Carvalho, Ricardo; Martins, Daniela Sofia Rodrigues; Castro, Tarsila Gabriel; Rodrigues, Ana Cristina; Costa, Bruna; Parreira, PaulaColloidal dispersions of pristine cellulose (nano- or microsized; fibrillar or particulate), are typically unstable in water due to interfiber/interparticle interactions. Carboxymethyl cellulose (CMC) is known to effectively stabilize these dispersions, allowing for full recovery of the properties upon redispersion after drying. However, the underlying mechanism has been unclear. This study investigated why CMC...
Assessment of the gastrointestinal fate of bacterial nanocellulose and its toxi...
Rodrigues, Ana Cristina Costa; Costa, Liliana Marisa Barros; Silva-Carvalho, Ricardo; Mota, Renato; Duarte-Silva, SaraBacterial nanocellulose (BNC), a nanofibrillar polysaccharide produced by certain acetic acid bacteria, may be used in food, pharma and many other applications. As with other nanoscale celluloses, the oral toxicology of BNC is still controversial. Therefore, we aimed to assess whether BNC is absorbed at the intestine following administration in Wistar rats. This is, to our knowledge, the first attempt to track ...
Overcoming the regulatory hurdles on nanocelluloses is bacterial cellulose abso...
Gama, F. M.; Mota, Renato Veloso; Rodrigues, Ana Cristina; Silva-Carvalho, Ricardo; Costa, Lígia; Martins, Daniela Sofia Rodrigues; Sampaio, PaulaThe potential of nanomaterials in food technology is nowadays well-established. However, their commercial use requires a careful risk assessment, in particular concerning the fate of nanomaterials in the human body. Bacterial NanoCellulose (BNC), a nanofibrillar polysaccharide, has been used as a food product for many years in Asia. However, given its nano-character, several toxicological studies must be perfor...
Tracking bacterial nanocellulose in animal tissues by fluorescence microscopy
Mota, Renato Veloso; Rodrigues, Ana Cristina; Silva-Carvalho, Ricardo; Costa, Lígia; Martins, Daniela; Sampaio, Paula; Dourado, Fernando; Gama, F. M.The potential of nanomaterials in food technology is nowadays well-established. However, their commercial use requires a careful risk assessment, in particular concerning the fate of nanomaterials in the human body. Bacterial nanocellulose (BNC), a nanofibrillar polysaccharide, has been used as a food product for many years in Asia. However, given its nano-character, several toxicological studies must be perfor...
Alginate-amphotericin B nanocomplexes covered by nanocrystals from bacterial ce...
Soeiro, Victória; Silva-Carvalho, Ricardo; Martins, Daniela; Parpot, Pier; Grotto, D.; Chaud, M. V.; Gama, F. M.; Jozala, A. F.Nanocomplexes systems made up natural poylymers have pharmacotechnical advantages such as increase of water solubility and a decrease of drugs toxicity. Amphotericin B (AmB) is a drug apply as anti-leishmanial and anti-fungal, however it has low water solubility and high toxicity, limiting its therapeutic application. With this in mind, the present study aimed to produce nanocomplexes composed by alginate (Alg)...
Inhalation of bacterial cellulose nanofibrils triggers an inflammatory response...
Silva-Carvalho, Ricardo; Silva, João P.; Ferreirinha, Pedro; Leitão, A.; Andrade, Fábia K.; Costa, Rui M. Gil da; Cristelo, C.; Rosa, Morsyleide F.In view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hanse...
Development of a water-soluble dextrin-amphotericin B conjugate for the treatme...
Fidalgo, João; Silva-Carvalho, Ricardo; Leal, S.; Cruz, T.; Tomás, A. M.; Parpot, Pier; Gama, F. M.Leishmaniasis is a life-threatening disease with a worldwide distribution and a huge impact especially in immunocompromised patients. Nowadays, the use of amphotericin B, an antifungal agent, or other marketed strategies to overcome this disease exhibit major clinical limitations. Thus, other strategies have been pursued to achieve better clinical treatments and decrease toxicity. In this work, a promising conj...
Delivery of nanogel formulations with antimicrobial peptides for the treatment ...
Silva-Carvalho, Ricardo; Cristelo, C.; Silva, João Pedro; Coutinho, Olga; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui; Gama, F. M.[Excerpt] Mycobacterium tuberculosis is the human pathogen that causes Tuberculosis (TB). In 2015, 10.4 million TB cases and 1.8 million deaths were reported, placing this disease alongside HIV/AIDS as the deadliest infectious diseases. Current treatments rely in the administration of a cocktail of four first-line antibiotics during 6 months and, in the worst case scenario, a long-lasting treatment (24 months) ...