110 documents found, page 1 of 11
Insights into bioengineering approaches for aging bone regeneration: strategies...
Xiao, Lan; Gao, Wendong; Wu, Jinfu; Erezuma, Itsasne; Dolatshahi-Pirouz, Alireza; Silva-Correia, Joana; Zhou, Yinghong; Sun, Antonia RujiaThe global accumulation of ageing population is a serious problem causing significant health and social burdens. Especially, aging results in reduced bone regeneration potential and increased risk of morbidities and mortality, which calls the urgent need for advanced therapeutic approaches to improve bone regeneration in the aged patients. The aging associated poor bone regeneration capacity can be attributed t...
Sustainable highly stretchable and tough gelatin-alkali lignin hydrogels for sc...
Decante, Guy Bandouin Henri; Cengiz, I. F.; Costa, João B.; Collins, Maurice N.; Reis, R. L.; Silva-Correia, Joana; Oliveira, Joaquim M.Hydrogels and bioinks obtained from gelatin (Gel) generally present poor mechanical properties and require a series of time-consuming and stepwise chemical processes to exhibit improved elasticity and resistance to fatigue. Alkali lignin (AL) is an underutilized by-product of the paper and pulp industry. It is a widely available and inexpensive biomaterial that presents enormous potential for high-value applica...
Hydrogels for tissue engineering and regenerative medicine: from fundamentals t...
Oliveira, J. M.; Silva-Correia, Joana; Reis, R. L.Hydrogels are among the most important and used biomaterials for tissue engineering and regenerative medicine (TERM) strategies. This is mostly due to their similarities to the native extracellular matrix of tissues. Their hydration capacity and suitable porosity are crucial for the process of exchanging of nutrients/metabolites and gases that is required for maintaining functions and growth of normal cells. By...
Preface [Hydrogels for tissue engineering and regenerative medicine: from funda...
Silva-Correia, Joana; Oliveira, Joaquim M.; Reis, R. L.Hydrogels are among the most important and used biomaterials for tissue engineering and regenerative medicine (TERM) strategies. This is mostly due to their similarities to the native extracellular matrix of tissues. Their hydration capacity and suitable porosity are crucial for the process of exchanging of nutrients/metabolites and gases that is required for maintaining functions and growth of normal cells. By...
Hydrogels for cancer treatment
Ribeiro, Viviana Pinto; Silva-Correia, Joana; Reis, R. L.; Oliveira, Joaquim M.The fundamental research on cancer development has been increasing in the last decade searching for more effective approaches applied in cancer therapy and diagnosis. The unique properties of hydrogels enabled researchers to develop innovative strategies for cancer diagnosis and associated therapies. Significant progresses were made in tumor models reconstruction, and hydrogels are largely responsible for this ...
Enzymatic crosslinked hydrogels
Decante, Guy Bandouin Henri; Reis, R. L.; Silva-Correia, Joana; Oliveira, Joaquim M.Crosslinking is a fundamental aspect of hydrogel formation and plays an essential role in the subsequent hydrogel properties in terms of mechanical and chemical stability. Enzyme-catalysed crosslinking has been developed rather recently compared to the physical and chemical methodologies. This technique allows for easy and efficient in situ forming of covalently bonded bioactive hydrogels under mild condition...
Spatial -omics technologies: the new enterprise in 3D breast cancer models
Pierantoni, Lara; Reis, R. L.; Silva-Correia, Joana; Oliveira, Joaquim M.; Heavey, SusanThe fields of tissue bioengineering, -omics, and spatial biology are advancing rapidly, each offering the opportunity for a paradigm shift in breast cancer research. However, to date, collaboration between these fields has not reached its full potential. In this review, we describe the most recently generated 3D breast cancer models regarding the biomaterials and technological platforms employed. Additionally, ...
Memory-shape hydrogels
Costa, João B.; Silva-Correia, Joana; Reis, R. L.; Oliveira, Joaquim M.Memory-shape hydrogels (MSH) are a class of hydrogels with tremendous potential to be used in the human body. Hydrogels exhibiting memory-shape features are considered â smartâ adjustable soft gels with a great tendency to repair either programmed or permanent temporal physical structures after being triggered by specific stimuli. These stimuli are usually based on pH changes, application of light, and changing...
Repairing annulus fibrosus fissures using methacrylated gellan gum combined wit...
Croft, Andreas F.; Ćorluka, Slavko; Fuhrer, Janine; Wöltje, Michael; Silva-Correia, Joana; Oliveira, J. M.; Erbach, Georg F.; Reis, R. L.Intervertebral disc (IVD) herniation often causes severe pain and is frequently associated with the degeneration of the IVD. As the IVD degenerates, more fissures with increasing size appear within the outer region of the IVD, the annulus fibrosus (AF), favoring the initiation and progression of IVD herniation. For this reason, we propose an AF repair approach based on methacrylated gellan gum (GG-MA) and silk ...
Ionic- and photo-crosslinked hydrogels
Lopes, Soraia Soares Vidigal; Reis, R. L.; Oliveira, Joaquim M.; Silva-Correia, JoanaThe extracellular matrix (ECM) plays a pivotal role in cellular functions and tissue regeneration. Thus, the development of ECM-mimetics such as the hydrogels for tissue engineering has been increasing over the years. In particular, the search for methods that do not involve the addition of harsh chemicals and allow triggering hydrogels polymerization in situ is attracting a great deal of attention. Among the n...