13 documents found, page 1 of 2
Inflammatory biomarkers and perinatal depression: A systematic review
Silva-Fernandes, Anabela; Marques, Margarida; Caparros-Gonzalez, Rafael; Fransson, Emma; Mesquita, Ana; Figueiredo, Bárbara; Skalkidou, AlkistisBackground Approximately 10 to 20% of pregnant women worldwide experience perinatal depression (PND), a depressive episode with onset during pregnancy or after childbirth. We performed a systematic review to identify, summarize and discuss studies on inflammatory biomarkers described in relation to PND. Method Inclusion criteria defined the selection of observational studies written in English, French, Spanish ...
Non-pharmacological treatment-related changes of molecular biomarkers in major ...
Irwin, Courtney L.; Coelho, Patrícia S.; Kluwe-Schiavon, Bruno; Silva-Fernandes, Anabela; Gonçalves, Óscar F.; Leite, Jorge; Carvalho, SandraBackground: Major depressive disorder (MDD) is a serious mood disorder and leading cause of disability. Despite treatment advances, approximately 30% of individuals with MDD do not achieve adequate clinical response. Better understanding the biological mechanism(s) underlying clinical response to specific psychopharmacological interventions may help fine tune treatments in order to further modulate their underl...
Inflammatory biomarkers and perinatal depression: a systematic review
Silva-Fernandes, Anabela; Conde, Ana; Marques, Margarida; Caparros-Gonzalez, Rafael A.; Fransson, Emma; Mesquita, Ana Raquel MarcelinoBackground: Approximately 10 to 20% of pregnant women worldwide experience perinatal depression (PND), a depressive episode with onset during pregnancy or after childbirth. We performed a systematic review to identify, summarize and discuss studies on inflammatory biomarkers described in relation to PND. Methods: Inclusion criteria defined the selection of observational studies written in English, French, Spani...
Non-pharmacological treatment-related changes of molecular biomarkers in major ...
Irwin, Courtney L.; Coelho, Patrícia S.; Kluwe-Schiavon, Bruno; Silva-Fernandes, Anabela; Gonçalves, Óscar F.; Leite, Jorge; Carvalho, SandraBackground: Major depressive disorder (MDD) is a serious mood disorder and leading cause of disability. Despite treatment advances, approximately 30% of individuals with MDD do not achieve adequate clinical response. Better understanding the biological mechanism(s) underlying clinical response to specific psychopharmacological interventions may help fine tune treatments in order to further modulate their underl...
Non-pharmacological treatment-related changes of molecular biomarkers in major ...
Irwin, Courtney L.; Coelho, Patrícia S.; Kluwe-Schiavon, Bruno; Silva-Fernandes, Anabela; Gonçalves, Óscar F.; Leite, Jorge; Carvalho, SandraBackground Major depressive disorder (MDD) is a serious mood disorder and leading cause of disability. Despite treatment advances, approximately 30% of individuals with MDD do not achieve adequate clinical response. Better understanding the biological mechanism(s) underlying clinical response to specific psychopharmacological interventions may help fine tune treatments in order to further modulate their underly...
Contribuição para uma gestão eficiente da colheita mecânica em olivais tradicio...
Almeida, Arlindo; Silva-Fernandes, Anabela; Ribeiro, A.C.; Cabo, PaulaNo Nordeste de Portugal predomina o olival tradicional, com 100 a 240 árvores.ha-1 Nestes olivais o sistema de colheita mais utilizado baseia-se num vibrador de troncos e apara-frutos. Com este sistema de colheita não se retira do olival a totalidade da produção. É usual colher 70% a 90% da produção de azeitona [Sola-Guirado et al, 2018]. Colher 80 % a 85% da produção já é um objetivo razoável [Castro-Garcia et...
A structural equation model of self-regulation and healthy habits as an individ...
Sousa, Sónia S.; Ferreira, Marisa M.; Cruz, Sara; Sampaio, Adriana; Silva-Fernandes, AnabelaObjective: The present study aims to explore the mediation role of self-regulation on health-related behaviors adoption or maintenance, mental health, and well-being during the COVID-19 confinement in a sample of adults in Portugal. Design: One-hundred fifty individuals (118 females, 32 males; Mage = 33.57 year; SD = 12.71) filled an online survey to assess self-regulation, healthy behaviors, mental health, and...
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson...
Rosa, Alexandra Isabel; Silva, Sara Carina Duarte; Silva-Fernandes, Anabela; Nunes, Maria João; Carvalho, Andreia Neves; Rodrigues, ElsaParkinson's disease (PD) is characterized by severe motor symptoms, and currently there is no treatment that retards disease progression or reverses damage prior to the time of clinical diagnosis. Tauroursodeoxycholic acid (TUDCA) is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD; however, its effect in PD motor symptoms has never been addressed. In the present work...
Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-J...
Esteves, Sofia; Duarte-Silva, Sara; Naia, Luana; Neves-Carvalho, Andreia; Teixeira-Castro, Andreia; Rego, Ana Cristina; Silva-Fernandes, AnabelaMachado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a compound with known neuroprotection activity, and previously shown to be effective in cell, fly and nematode model...
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-ph...
Chatterjee, Arpita; Saha, Saikat; Chakraborty, Anirban; Silva-Fernandes, Anabela; Mandal, Santi M.; Neves-Carvalho, Andreia; Liu, YongpingDNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates. Several neurological diseases have already been identified as being due to a deficiency in DNA end-processing activities. Two common dirty ends, 3'-P and 5'-OH, are processed by mammalian polynucleotide kinase 3'-phosphatase...