Encontrados 3 documentos, a visualizar página 1 de 1
Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with ...
Pereira, Eliane dos Santos; Silva-Fernandes, Isabelle Joyce de Lima; Costa, Débora Menezes da; Burbano, Rommel Mario RodriguezSNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective w...
Helicobacter pylori genotype and polymorphisms in DNA repair enzymes : where do...
Silva-Fernandes, Isabelle Joyce de Lima; Silva, Thayse Azevedo da; Agnez-Lima, Lucymara Fassarella; Ferreira, Márcia Valéria PitomveiraOne of the mechanisms proposed by which H. pylori causes gastric cancer (GC) is through DNA damage due to chronic inflammation. Genomic integrity is guaranteed by repair enzymes such as APE-1, OGG-1, and PARP-1. Host genetic polymorphisms associated with the bacterial strain may influence the ability to repair the damage, contributing to the development of H. pylori-associated GC. The aim of this study was to d...
Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in ga...
Lima, Valeska Portela; Silva-Fernandes, Isabelle Joyce de Lima; Alves, Markênia Kélia Santos; Rabenhorst, Silvia Helena BaremPurpose: To investigate the frequency and the association of vac A alleles, cag A, cag E and vir B11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods : One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vac A alleles, cag A, cag E and vir B11. Results : The distribution of cases according to ...