4 documents found, page 1 of 1
Metabolic regulation of the host-fungus interaction: from biological principles...
Silva-Gomes, Rita; Caldeira, Inês; Fernandes, Raquel; Fernandes, Raquel; Cunha, Cristina; Carvalho, AgostinhoFungal infections present a significant global public health concern, impacting over 1 billion individuals worldwide and resulting in more than 3 million deaths annually. Despite considerable progress in recent years, the management of fungal infections remains challenging. The limited development of novel diagnostic and therapeutic approaches is largely attributed to our incomplete understanding of the pathoge...
Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ul...
Fraga, Alexandra G.; Branquinho, Gabriela Alexandra Trigo; Murthy, Ramya K.; Akhtar, Shamim; Hebbur, Madhavi; Pacheco, Ana Rita; Dominguez, JuanBuruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Although the current antibiotic treatment for BU is effective, daily administrations for a prolonged period of time, combined with potential risk of severe side effects, negatively impact on patient adherence. In that sense, we tested the efficacy of an alternative strategy based on Lysin B (LysB), a phage encoded lipolytic enzyme...
Genetic variation in autophagy-related genes influences the risk and phenotype ...
Capela, C.; Dossou, A. D.; Silva-Gomes, Rita; Sopoh, G. E.; Makoutode, M.; Menino, João Filipe Marques Almeida Ferreira; Fraga, Alexandra GabrielIntroduction Buruli ulcer (BU) is a severe necrotizing human skin disease caused by Mycobacterium ulcerans. Clinically, presentation is a sum of these diverse pathogenic hits subjected to critical immune-regulatory mechanisms. Among them, autophagy has been demonstrated as a cellular process of critical importance. Since microtubules and dynein are affected by mycolactone, the critical pathogenic exotoxin produ...
Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tub...
Silva, João P.; Gonçalves, Carine; Costa, C.; Sousa, Jeremy; Silva-Gomes, Rita; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui; Gama, F. M.uberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, recently joined HIV/AIDS on the top rank of deadliest infectious diseases. Low patient compliance due to the expensive, long-lasting and multi-drug standard therapies often results in treatment failure and emergence of multi-drug resistant strains. In this scope, antimicrobial peptides (AMPs) arise as promising candidates for T...