2 documents found, page 1 of 1
Genetic disruption of NRF2 promotes the development of necroinflammation and li...
Duarte, T.; Caldas, C.; Santos, A.; Silva-Gomes, S.; Santos-Gonçalves, A.; Martins, M.; Porto, G.; Lopes, J.In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical determinant of hepa...
Endogenous cathelicidin production limits inflammation and protective immunity ...
Santos, J. C.; Silva-Gomes, S.; Silva, João P.; Gama, F. M.; Rosa, G.; Gallo, R. L.; Appelberg, R.The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in the innate immune response against microbial pathogens. Cathelicidins are widely distributed amongst living organisms, and the antimicrobial peptides generated by proteolysis of the precursor forms are typically cationic and [alpha]-helical, a structure that facilitates their interaction and insertion into anionic bac...