46 documents found, page 1 of 5
Mauriac syndrome
Oliveira Torres, João; Martins, Diana; Abegão Matias, Alexandra; Gião, Nuno; Dutra, Eduardo; Malheiro, Rui; Mendes, Milena; Silva-Nunes, Josépersons; Mauriac syndrome is a rare complication in patients with type 1 diabetes. It presents with poor glycemic control and hepatomegaly due to extensive liver glycogen deposition. Whether behavioral or genetic factors play key roles in its pathophysiology remains a subject of debate. We present the case of a 19-year-old woman with poorly controlled type 1 diabetes mellitus and persistently elevated liver enz...
GLP-1 receptor agonists versus testosterone in male reproductive health: a crit...
Oliveira Torres, João; Lima, Mariana Guilherme; Bouça, Bruno; Silva-Nunes, JoséObesity and hypogonadism share a complex relationship, with obesity-related comorbidities such as type 2 diabetes (T2D), obstructive sleep apnoea (OSA) and cardiovascular disease contributing to hypogonadism. Obesity is associated with impaired androgen secretion, bioavailability and metabolism. The studies have demonstrated an inverse correlation between fat mass and total, free testosterone and sex hormone-bi...
Cultural Translation and Validation of the Bariatric Quality of Life Index to E...
Rego de Figueiredo, Inês; Vasques de Carvalho, Miguel; Cunha, Nelson; Martins, Diana; Silva-Nunes, JoséIntroduction: Obesity is a chronic noncommunicable disease, defined by a body mass index over 30 kg/m2. Its impact is not restricted to its association with higher risks of mortality and morbidity from other noncommunicable diseases, but also with a decrease in quality of life (QoL). There are several tools to assess QoL, from generic health-related tools to obesity-related specific ones. However, to assess QoL...
Modern Management of Cardiometabolic Continuum: From Overweight/Obesity to Pred...
Janez, Andrej; Muzurovic, Emir; Bogdanski, Pawel; Czupryniak, Leszek; Fabryova, Lubomira; Fras, Zlatko; Guja, Cristian; Haluzik, Martin; Kempler, PeterThe increasing global incidence of obesity and type 2 diabetes mellitus (T2D) underscores the urgency of addressing these interconnected health challenges. Obesity enhances genetic and environmental influences on T2D, being not only a primary risk factor but also exacerbating its severity. The complex mechanisms linking obesity and T2D involve adiposity-driven changes in β-cell function, adipose tissue function...
Telomeres are shorter in Portuguese obese adults
Duarte, Catarina; Braz, Maria Teresa; Marques-Ramos, Ana; Silva-Nunes, José; Veiga, Luisa; Brito, MiguelObesity is a clinical condition characterized by an abnormal accumulation of adipose tissue with an increased risk of developing illnesses such as type 2 diabetes, cardiovascular disease, and cancer. In obesity, the secretion of proinflammatory adipokines contributes to oxidative stress that can lead to a decline in the length of telomeres. Telomeres are structures of repetitive sequences delimiting the chromos...
Metformin in SARS-CoV-2 infection: A hidden path - from altered inflammation to...
Pedrosa, Ana Realista; Martins, Diana Cruz; Rizzo, Manfredi; Silva-Nunes, JoséSARS-CoV-2 infection has been a major threat to human health and a huge challenge to Medicine. In only two years, COVID-19 affected >350 million people, causing >5.6 million deaths. Chronic inflammatory states, such as diabetes or obesity, are known risk factors for COVID-19 poorest outcomes, with higher risk for disease severity and greater mortality. Metformin remains on the first line of the management of hy...
2023 UPDATE: Luso-Brazilian evidence-based guideline for the management of anti...
Bertoluci, Marcello Casaccia; Júnior, Wellington S. Silva; Valente, Fernando; Araujo, Levimar Rocha; Lyra, Ruy; Castro, João Jácome de; Raposo, JoãoBackground The management of antidiabetic therapy in people with type 2 diabetes (T2D) has evolved beyond gly‑ cemic control. In this context, Brazil and Portugal defned a joint panel of four leading diabetes societies to update the guideline published in 2020. Methods The panelists searched MEDLINE (via PubMed) for the best evidence from clinical studies on treating T2D and its cardiorenal complications. The p...
Diagnosis of 17-alpha hydroxylase deficiency performed late in life in a patien...
Bouça, Bruno; Cascão, Mariana; Fiúza, Pedro; Amaral, Sara; Bogalho, Paula; Silva-Nunes, JoséSummary: 17-Alpha-hydroxylase deficiency (17OHD) is a rare autosomal recessive disease, representing 1% of cases of congenital adrenal hyperplasia. A 44-year-old female presented to the emergency department complaining of generalized asthenia and polyarthralgia for about 2 weeks. On examination, she was hypertensive (174/100 mmHg), and laboratory results revealed hypokalemia and hypocortisolism. She had an unch...
Metformin in SARS-CoV-2 infection: a hidden path - from altered inflammation to...
Pedrosa, Ana Realista; Martins, Diana Cruz; Rizzo, Manfredi; Silva-Nunes, JoséSARS-CoV-2 infection has been a major threat to human health and a huge challenge to Medicine. In only two years, COVID-19 affected >350 million people, causing >5.6 million deaths. Chronic inflammatory states, such as diabetes or obesity, are known risk factors for COVID-19 poorest outcomes, with a higher risk for disease severity and greater mortality. Metformin remains on the first line of the management of ...
Absolute hyperglycemia versus stress hyperglycemia ratio for the prognosis of h...
Matias, Alexandra A.; Manique, Inês; Sabino, Teresa; Rego, Teresa; Mihon, Claudia; Panarra, António; Rizzo, Manfredi; Silva-Nunes, JoséDiabetes is a risk factor for the greater severity of coronavirus disease 2019 (COVID-19). The stress hyperglycemia ratio (SHR) is an independent predictor of critical illness, and it is reported to have a stronger association than absolute hyperglycemia. The aim of this study was to assess the relationship between absolute hyperglycemia and SHR with the severity of COVID-19 since there are no studies investiga...