4 documents found, page 1 of 1
Sickle cell disease and pregnancy: analysis of 34 patients followed at the Regi...
Silva-Pinto,Ana Cristina; Ladeira,Simery de Oliveira Domingues; Brunetta,Denise Menezes; Santis,Gil Cunha De; Angulo,Ivan de Lucena; Covas,Dimas TadeuObjective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complication...
Clinical and hematological effects of hydroxyurea therapy in sickle cell patien...
Silva-Pinto,Ana Cristina; Angulo,Ivan Lucena; Brunetta,Denise Menezes; Neves,Fabia Idalina Rodrigues; Bassi,Sarah Cristina; Santis,Gil Cunha DeCONTEXT AND OBJECTIVES Sickle cell disease (SCD) is the most common genetic disorder among people of African descent, affecting approximately 3,500 newborns each year in Brazil. Hydroxyurea (HU) is the only effective drug to treating patients with SCD, thereby reducing morbidity and mortality. The objective was to analyze the effects of HU on SCD patients at our institution. DESIGN AND SETTING Retrospective stu...
Molecular and clinical evaluation of the acute human parvovirus B19 infection: ...
Slavov,Svetoslav Nanev; Kashima,Simone; Silva-Pinto,Ana Cristina; Amarilla,Alberto Anastacio; Aquino,Victor Hugo; Covas,Dimas TadeuHuman parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the oth...
Hematological differences between patients with different subtypes of sickle ce...
Neves,Fabia; Menezes Neto,Osvaldo Alves; Polis,Larissa Bueno; Bassi,Sarah Cristina; Brunetta,Denise Menezes; Silva-Pinto,Ana CristinaOBJECTIVE: Sickle cell anemia and the interaction S/Beta thalassemia differ in hematological values due to microcytosis and hypochromia caused by the thalassemic mutation. The clinical benefit of long-term hydroxyurea treatment is undeniable in sickle cell disease with monitoring of the biological action of the drug being by the complete blood count. The objective of this work is to compare changes in some of t...