8 documents found, page 1 of 1
Effects of oral supplementation of black-eyed-bean (Vigna unguiculata) in ICR m...
Ferreira, T; Silva-Reis, R; Mendes, BAL; Faustino-Rocha, AI; Carvalho, M; Castro I; Carnide, V; Coutinho, J; Gama, A; Rosa, E; Oliveira, PAGrain legumes are a main source of nutrients in some countries. Black-eyed-bean (BEB) (Vigna unguiculata), a member of theFabaceae family, is a grain legume consumed worldwide due to its high content of bioactive molecules that promote human health. This study aimed to evaluate the effects of 70% BEB flour (BEBF) (w/w) supplementation in ICR healthy mice for 13 weeks. Body and organs weights, as well as food an...
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical...
Silva, AFR; Silva-Reis, R; Ferreira, R; Oliveira, Paula A; Faustino-Rocha, Ana I; Pinto, ML; Coimbra, MA; Silva, AMS; Cardoso, SAbstract The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate th...
Studying and analyzing humane endpoints in the fructose-fed and streptozotocin-...
Silva-Reis, R; Faustino-Rocha, Ana I; Silva, J; Valada, A; Azevedo, T; Anjos, L; Gonçalves, L; Pinto, ML; Ferreira, R; Silva, AM; Cardoso, SMThis study assessed a humane endpoint scoring system to detect animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced (fructose-fed and streptozotocin (STZ) administration) groups. Induced animals drank 10% fructose for 14 days, then received STZ (40 mg/kg) intraperitoneally. Weekly monitoring of body weight, water, and food consumption, 14 parameters ...
Animal welfare in diabetes research: a humane endpoint scoring system
Faustino-Rocha, Ana I; Silva-Reis, R; Silva, J; Valada, A; Azevedo, T; Anjos, L; Silva, MAS; Cardoso, SM; Oliveira, PAHumane endpoints are increasingly being used in animal experiments to ensure compliance with ethical regulations, namely the 3Rs policy. This study aimed to develop a clear humane endpoint (HE) scoring system for a streptozotocin (STZ)-induced diabetes model in male Sprague-Dawley rats. The rats were divided into a control (n=8) and an induced (n=16) group, with the latter receiving 10% fructose in their drinki...
Characterizing the molecular and physiological changes associated with colorect...
Silva-Reis, R; Faustino-Rocha, Ana I; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias- Aguierre, CE; Cortés-Martín, A; Selma, MVCharacterizing the molecular and physiological changes associated with colorectal cancer in wistar rats
Animal welfare in diabetes research: a humane endpoint scoring system
Faustino-Rocha, Ana I; Silva-Reis, R; Silva, J; Valada, A; Azevedo, T; Anjos, L; Silva, MAS; Cardoso, SM; Oliveira, PAaustino-Rocha AI, Silva-Reis R, Silva J, Valada A, Azevedo T, Anjos L, Silva MAS, Cardoso SM, Oliveira PA. 2023. Animal welfare in diabetes research: a humane endpoint scoring system. 3rd International Conference on Diabetes, Endocrinology & Obesity, 20 a 21 de março.
Natural products-based antiangiogenic agents: new frontiers in cancer therapy
Azevedo, T; Ferreira, T; Pena-Corona, SI; Cortes, H; Silva-Reis, R; Gil da Costa, RM; Faustino-Rocha, Ana I; Oliveira, PA; Calina, D; Cardoso, MAngiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product-based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natur...
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical...
Silva, AFR; Silva-Reis, R; Ferreira, R; Oliveira, PA; Faustino-Rocha, AI; Pinto, ML; Coimbra, MA; Silva, AMS; Cardoso, SThe World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate the effect ...